CAJ | 학술논문

目的：探讨中药复方治疗肾纤维化的用药规律。方法计算机检索中文科技期刊数据库、中国期刊全文数据库、中国生物医学文献服务系统、万方数据库中治疗慢性肾病肾纤维化的中药复方，建立相应数据库，采用频数分析、聚类分析、关联规则对复方中主要药物、药对(药组)规律进行分析。结果治疗肾纤维化38首中药复方涉及95味中药，总频次为362次。对高频药物聚类分析，主要为补益类、化瘀类、利湿类；经关联规则分析，共得药对规则18条，药组(3味药或4味药)规则31条。结论大多数医家治疗肾纤维化多用补益、活血化瘀药物。
목적：탐토중약복방치료신섬유화적용약규률。방법계산궤검색중문과기기간수거고、중국기간전문수거고、중국생물의학문헌복무계통、만방수거고중치료만성신병신섬유화적중약복방，건립상응수거고，채용빈수분석、취류분석、관련규칙대복방중주요약물、약대(약조)규률진행분석。결과치료신섬유화38수중약복방섭급95미중약，총빈차위362차。대고빈약물취류분석，주요위보익류、화어류、리습류；경관련규칙분석，공득약대규칙18조，약조(3미약혹4미약)규칙31조。결론대다수의가치료신섬유화다용보익、활혈화어약물。
Objective To study the regularity of compound herbal formulae for renal fibrosis (RF). Methods Compound herbal formulae published about the treatment of RF in databases of Chinese Science and Technology Periodical Database, CNKI, Chinese Biomedical Literature Service System, and Wanfang Databasewere searched and collected. A database was established for data mining by using frequency analysis, cluster analysis and association rule analysis. Regularity of key herbs and groups of herbs was discussed. Results There were 38 prescriptions (totally 95 herbs) in the compound herbal formulae for RF, and the total frequency was 362 times. High frequency herbs under cluster analysis were classified into 3 clusters including tonic, hemorheologic agent and promoting diuresis drugs. The rules in pair of herbs were 18, and rules in group of herbs were 31 (three or four medicinal herbs) by using association rule analysis. Conclusion Tonifying promoting blood circulation and removing blood stasis"is a common sense for treating RF.