CAJ | 학술논문

目的：观察临床常用的13种β‐内酰胺类抗菌药物对果糖胺检测项目的干扰情况。方法将抗菌药物用注射用水配制成系列溶液，按5％体积加入到新鲜的混合血清中，评价不同抗菌药物对果糖胺检测结果的干扰。结果头孢硫脒和替卡西林钠/克拉维酸钾的血药浓度分别达到37．5mg/L和247．5μg/mL时，开始对果糖胺的检测产生正干扰，但干扰程度与果糖胺血清浓度无关。结论头孢硫脒和替卡西林钠/克拉维酸钾对果糖胺检测结果存在干扰。
목적：관찰림상상용적13충β‐내선알류항균약물대과당알검측항목적간우정황。방법장항균약물용주사용수배제성계렬용액，안5％체적가입도신선적혼합혈청중，평개불동항균약물대과당알검측결과적간우。결과두포류미화체잡서림납/극랍유산갑적혈약농도분별체도37．5mg/L화247．5μg/mL시，개시대과당알적검측산생정간우，단간우정도여과당알혈청농도무관。결론두포류미화체잡서림납/극랍유산갑대과당알검측결과존재간우。
Objective To evaluate the interference of 13 kinds of β‐lactam antibiotics in fructosamine detection .Methods A se‐ries of solution of antimicrobial drugs were formulated with water for injection ,and added into the mixture fresh serum volume by 5% .Interfere with antimicrobial drugs on the test results of fructosamine were evaluated .Results When the blood concentrations of cefathiamidine and ticarcillin sodium/clavulanate potassium were up to 37 .5 mg/L and 247 .5 μg/mL respectively ,they began to produce positive interference on fructosamine detection .However ,the degree of interference was not correlated to the serum concen‐tration of fructosamine .Conclusion Cephathiamidine and ticarcillin sodium/clavulanate potassium have positive interference on fructosamine detection .