CAJ | 학술논문

目的：比较荧光原位杂交（FISH）技术及细胞学技术检测尿脱落细胞对膀胱尿路上皮肿瘤诊断价值。方法采用CSP3/CSP7组合探针和GLPp16/CSP17组合探针对膀胱尿路上皮肿瘤疑似患者的尿脱落细胞进行FISH检测，同时采用细胞学技术检测尿脱落细胞，比较2种方法的灵敏度和特异度。结果FISH技术筛查膀胱尿路上皮肿瘤的灵敏度和特异度分别为92．5％和85．0％，细胞学技术的灵敏度和特异度分别为27．5％和90．0％。FISH技术的灵敏度显著高于细胞学技术（P＜0．05），但2种方法的特异度差异无统计学意义（P＞0．05）。结论FISH技术有望成为筛查膀胱尿路上皮肿瘤的新方法。
목적：비교형광원위잡교（FISH）기술급세포학기술검측뇨탈락세포대방광뇨로상피종류진단개치。방법채용CSP3/CSP7조합탐침화GLPp16/CSP17조합탐침대방광뇨로상피종류의사환자적뇨탈락세포진행FISH검측，동시채용세포학기술검측뇨탈락세포，비교2충방법적령민도화특이도。결과FISH기술사사방광뇨로상피종류적령민도화특이도분별위92．5％화85．0％，세포학기술적령민도화특이도분별위27．5％화90．0％。FISH기술적령민도현저고우세포학기술（P＜0．05），단2충방법적특이도차이무통계학의의（P＞0．05）。결론FISH기술유망성위사사방광뇨로상피종류적신방법。
Objective To compare the diagnostic values of the detection of urine exfoliated cells by FISH and cytology technolo‐gy in bladder urothelial tumor .Methods The combination probes of CSP3/CSP7 and GLPp16/CSP17 were both used in the FISH detection of urine exfoliated cells from suspected patients with bladder urothelial tumor .The urine exfoliated cells were detected by cytology technology at the same time .The sensitivity and the specificity of the two methods were compared .Results The sensitivi‐ty and specificity of FISH for bladder urothelial tumor screening were 92 .5% and 85 .0% respectively ,and those of cytology tech‐nology were 27 .5% and 90 .0% respectively .The sensitivity of FISH was significantly higher than that of cytology technology (P<0 .05) ,however ,the specificity differences between FISH and cytology technology were not statistically significant (P>0 .05) .Conclusion FISH is expected to become a new method for the screening of bladder urothelial tumor .