CAJ | 학술논문

目的：分析2型糖尿病并发脑梗死的临床危险因素。方法选取确诊为2型糖尿病的患者508例，分为A组（并发脑梗死，n＝240）和B组（无脑梗死，n＝268）。记录2组患者的基本临床资料并检测其血糖、血脂、糖化血红蛋白（HbA1c）、血β2微球蛋白、尿β2微球蛋白、尿微量清蛋白、空腹胰岛素、空腹C肽等指标生化指标和凝血指标。结果A组年龄、糖尿病发病年龄、高血压病程及收缩压与B组相比差异有统计学意义（P＜0．05）。A组高血压及冠心病的发病率明显高于B组（P＜0．05）。A组HbA1c、载脂蛋白B（ApoB）、空腹胰岛素、空腹C肽、脂蛋白a、同型半胱氨酸（Hcy）、血β2微球蛋白、尿β2微球蛋白、尿微量清蛋白与B组相比，差异均有统计学意义（P＜0．05）。A组抗凝血酶Ⅲ水平明显低于B组（P＜0．05）。结论年龄、高血压、HbA1c、ApoB、空腹胰岛素、空腹C肽、脂蛋白a、Hcy等是2型糖尿病患者并发脑梗死的危险因素。
목적：분석2형당뇨병병발뇌경사적림상위험인소。방법선취학진위2형당뇨병적환자508례，분위A조（병발뇌경사，n＝240）화B조（무뇌경사，n＝268）。기록2조환자적기본림상자료병검측기혈당、혈지、당화혈홍단백（HbA1c）、혈β2미구단백、뇨β2미구단백、뇨미량청단백、공복이도소、공복C태등지표생화지표화응혈지표。결과A조년령、당뇨병발병년령、고혈압병정급수축압여B조상비차이유통계학의의（P＜0．05）。A조고혈압급관심병적발병솔명현고우B조（P＜0．05）。A조HbA1c、재지단백B（ApoB）、공복이도소、공복C태、지단백a、동형반광안산（Hcy）、혈β2미구단백、뇨β2미구단백、뇨미량청단백여B조상비，차이균유통계학의의（P＜0．05）。A조항응혈매Ⅲ수평명현저우B조（P＜0．05）。결론년령、고혈압、HbA1c、ApoB、공복이도소、공복C태、지단백a、Hcy등시2형당뇨병환자병발뇌경사적위험인소。
Objective To analyze the clinical risk factors of type 2 diabetes complicated with cerebral infarction .Methods 508 patients with type 2 diabetes were selected and divided into two groups :group A (complicated with cerebral infarction ,n=240) and group B (without cerebral infarction ,n=268) .The basic clinical information of two groups were recorded .The coagulation indica‐tors and biochemical indicators (including blood glucose ,blood lipid ,HbA1c ,blood β2 microglobulin ,urineβ2 microglobulin ,urine microalbuminuria ,fasting insulin ,fasting C peptide etc) were detected respectively .Results There were significant differences in age ,age at onset of diabetes ,duration of hypertension and systolic blood pressure between group A and group B (P<0 .05) .The in‐cidence of hypertension and coronary heart disease in group A were higher than group B (P<0 .05) .Comparing with group B ,the levels of HbA1c ,ApoB ,fasting insulin ,fasting C‐peptide ,lipoprotein (a) ,Hcy ,blood β2 microglobulin ,urineβ2 microglobulin ,and urine microalbuminuria of group A were significantly different (P<0 .05) .The ATⅢ level of group A was significantly lower than that of group B (P<0 .05) .Conclusion The risk factors of type 2 diabetes complicated with cerebral infarction include age ,hyper‐tension ,HbA1c ,ApoB ,fasting insulin ,fasting C‐peptide ,lipoprotein (a) ,Hcy ,etc make diabetics be more prone to cerebral infarc‐tion ect .