CAJ | 학술논문

目的：探讨尿液中胱抑素C（CysC）和β‐N‐乙酰氨基葡萄糖苷酶（NAG）联合检测在肾小管损伤中的价值。方法收集130例肾小管损伤患者（病例组）和100例健康人（健康对照组）的尿液标本，分别检测其CysC浓度和NAG活性。结果联合检测CysC和NAG对肾小管损伤的辅助诊断敏感度为85．4％，特异度为89．6％，阳性预测值为82．1％。干预治疗前后比较，病例组患者尿液CysC浓度和NAG活性水平差异均有统计学意义（P＜0．05）。结论尿液CysC和NAG联合检测对肾小管损伤的诊断和疗效监测价值显著。
목적：탐토뇨액중광억소C（CysC）화β‐N‐을선안기포도당감매（NAG）연합검측재신소관손상중적개치。방법수집130례신소관손상환자（병례조）화100례건강인（건강대조조）적뇨액표본，분별검측기CysC농도화NAG활성。결과연합검측CysC화NAG대신소관손상적보조진단민감도위85．4％，특이도위89．6％，양성예측치위82．1％。간예치료전후비교，병례조환자뇨액CysC농도화NAG활성수평차이균유통계학의의（P＜0．05）。결론뇨액CysC화NAG연합검측대신소관손상적진단화료효감측개치현저。
Objective To discuss the diagnostic value of combined utilization of urinary cystatin C (CysC) and β‐N‐acetyl‐glu‐cosaminidase (NAG) in renal tubules injury .Methods Urine samples were collected from 130 cases of patients with renal tubular damage (case group) and 100 cases of health individuals (normal control group) ,respectively .The concentration of CysC and the activity of NAG in urine were detected .Results The sensitivity ,specificity ,and positive predictive value of combined utilization of CysC and NAG in diagnosis of renal tubules damage were 85 .4% ,89 .6% and 82 .1% ,respectively .The concentration of CysC and the activity of NAG in case group after treatment were both significantly different from those before treatment (P<0 .05) .Conclu‐sion Combined utilization of urinary CysC and NAG has a significant value for the diagnosis and the therapeutic monitoring in re‐nal tubules injury .