CAJ | 학술논문

目的：探讨端粒酶及端粒酶催化亚单位（hTERT）在卵巢肿瘤组织中的表达及其临床意义。方法分别检测恶性卵巢肿瘤、良性卵巢肿瘤、正常卵巢组织中的端粒酶活性及hTERTmRNA表达水平，并对结果进行分析。结果与良性卵巢肿瘤和正常卵巢组织比较，恶性卵巢肿瘤组织中端粒酶活性增强、hTERTmRNA表达水平增高，差异均有统计学意义（P＜0．05）。结论端粒酶在恶性卵巢肿瘤的发生、发展中起着重要作用，检测端粒酶活性有助于恶性卵巢肿瘤的早期诊断。
목적：탐토단립매급단립매최화아단위（hTERT）재란소종류조직중적표체급기림상의의。방법분별검측악성란소종류、량성란소종류、정상란소조직중적단립매활성급hTERTmRNA표체수평，병대결과진행분석。결과여량성란소종류화정상란소조직비교，악성란소종류조직중단립매활성증강、hTERTmRNA표체수평증고，차이균유통계학의의（P＜0．05）。결론단립매재악성란소종류적발생、발전중기착중요작용，검측단립매활성유조우악성란소종류적조기진단。
Objective To discuss the expression and clinical significance of telomerase and hTERT in ovarian neoplasm tissues . Methods The activities of telomerase and the expression levels of hTERT mRNA were detected in the tissues of malignant ovarian neoplasm ,benign ovarian neoplasm and normal ovarian respectively ,and the results were analyzed .Results Comparing with the tis‐sues of benign ovarian neoplasm and normal ovarian ,the activity of telomerase and the expression level of hTERT mRNA increased in malignant ovarian neoplasm tissues ,and the differences were statistically significant(P< 0 .05) .Conclusion The telomerase plays an important role in the occurrence and development of malignant ovarian neoplasm .The detection of telomerase activity can help in early diagnosis of malignant ovarian neoplasm .