CAJ | 학술논문

目的：探讨血脂、雌激素和肝功能水平对妊娠期肝内胆汁淤积症（ICP）胎儿窘迫的预测作用。方法分别检测轻度ICP组、重度ICP组、对照组的血脂、雌激素、肝功能指标，并对结果进行分析。结果三酰甘油、总胆固醇、低密度脂蛋白水平与雌二醇水平均呈正相关。多变量Logistic回归分析发现甘氨胆酸（OR＝8．24，P＝0．01）、雌二醇（OR＝4．46，P＝0．02）对ICP患者胎儿窘迫有预测作用。结论雌二醇与甘氨胆酸可能成为预测ICP患者胎儿窘迫较好的指标。
목적：탐토혈지、자격소화간공능수평대임신기간내담즙어적증（ICP）태인군박적예측작용。방법분별검측경도ICP조、중도ICP조、대조조적혈지、자격소、간공능지표，병대결과진행분석。결과삼선감유、총담고순、저밀도지단백수평여자이순수평균정정상관。다변량Logistic회귀분석발현감안담산（OR＝8．24，P＝0．01）、자이순（OR＝4．46，P＝0．02）대ICP환자태인군박유예측작용。결론자이순여감안담산가능성위예측ICP환자태인군박교호적지표。
Objective To explore the predictive values of the levels of blood lipids ,liver function and estrogen for the fetal dis‐tress in intrahepatic cholestasis of pregnancy (ICP) patients .Methods The indicators of blood lipids ,liver function and estrogen of mild IPC group ,severe ICP group and control group were detected respectively ,and the results were analyzed .Results The levels of triglycerides ,total cholesterol and low‐density lipoprotein were positively related to estradiol levels .Multivariate logistic regres‐sion analysis showed that cholyglycine (OR=8 .24 ,P=0 .01) and estradiol(OR=4 .46 ,P=0 .02) were significant for prediction of fetal distress in ICP patients .Conclusion Estradiol and cholyglycine levels may be better indicators for the prediction of fetal dis‐tress in ICP patients .