CAJ | 학술논문

目的：探讨血浆同型半胱氨酸（Hcy）和B型尿钠肽（BNP）联合检测对急性心肌梗死（AMI）的诊断和预后价值。方法选取140例AMI患者（AMI组）及125例健康人（对照组），分别检测其血浆Hcy和BNP水平，并对结果进行分析。结果治疗前，AMI组血浆BNP[（585．24±155．37）pg/mL]和Hcy[（33．4±9．84）μmol/L]水平明显升高，与对照组比较差异有统计学意义（P＜0．05）。AMI患者经治疗后血浆BNP和Hcy水平显著降低，与治疗前比较差异有统计学意义（P＜0．05）。在随访期间，发生心血管事件的AMI患者血浆BNP和Hcy水平明显高于未发生心血管事件的AMI患者，差异具有统计学意义（P＜0．05）。结论BNP和Hcy可作为指导临床诊断和治疗AMI的重要指标，并可作为预测AMI患者远期康复的重要参数。
목적：탐토혈장동형반광안산（Hcy）화B형뇨납태（BNP）연합검측대급성심기경사（AMI）적진단화예후개치。방법선취140례AMI환자（AMI조）급125례건강인（대조조），분별검측기혈장Hcy화BNP수평，병대결과진행분석。결과치료전，AMI조혈장BNP[（585．24±155．37）pg/mL]화Hcy[（33．4±9．84）μmol/L]수평명현승고，여대조조비교차이유통계학의의（P＜0．05）。AMI환자경치료후혈장BNP화Hcy수평현저강저，여치료전비교차이유통계학의의（P＜0．05）。재수방기간，발생심혈관사건적AMI환자혈장BNP화Hcy수평명현고우미발생심혈관사건적AMI환자，차이구유통계학의의（P＜0．05）。결론BNP화Hcy가작위지도림상진단화치료AMI적중요지표，병가작위예측AMI환자원기강복적중요삼수。
Objective To explore the clinical significance of plasma homocysteine (Hcy) and brain natriwetic peptide (BNP) joint detection in the diagnosis and prognosis of acute myocardial infarction (AMI) .Methods The plasma Hcy and BNP levels of 140 cases of AMI patients (AMI group) and 125 cases of healthy people (control group) were detected respectively ,and the results were analyzed .Results Before treatment ,the plasma BNP and Hcy levels of AMI group were (585 .24 ± 155 .37)pg/mL and (33 .4 ± 9 .84)μmol/L respectively ,which were significantly higher than those of control group (P< 0 .05) .After treatment ,the plasma BNP and Hcy levels were both significantly lower than those before treatment (P<0 .05) .During the follow‐up period ,the plasma BNP and Hcy levels of the patients with cardiovascular events were significantly higher than the patients without cardiovas‐cular events(P<0 .05) .Conclusion BNP and Hcy can be used as vital factors to guide clinical diagnosis and treatment of AMI ,and they maybe important parameters to predict prognosis .