国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
22期
3013-3014
,共2页
顾猛%丁翠君%陆冬明%高春标%陈朝
顧猛%丁翠君%陸鼕明%高春標%陳朝
고맹%정취군%륙동명%고춘표%진조
特异性IgE%特异性IgG4%过敏性哮喘%过敏性鼻炎
特異性IgE%特異性IgG4%過敏性哮喘%過敏性鼻炎
특이성IgE%특이성IgG4%과민성효천%과민성비염
specific IgE%specific IgG4%allergic asthma%allergic rhinitis
目的：探讨血清特异性IgE（sIgE）和特异性IgG4（sIgG4）检测在儿童过敏性哮喘及过敏性鼻炎中的临床应用价值。方法采用ELISA法对85例过敏性哮喘组患儿、72例过敏性鼻炎组患儿及60例对照组健康儿童血清中sIgE和sIgG4进行检测。采用ROC曲线分析sIgE和sIgG4对过敏性哮喘和过敏性鼻炎的诊断效能。结果过敏性哮喘组和过敏性鼻炎组治疗前血清sIgE和sIgG4水平均明显高于对照组，差异有统计学意义（P＜0．01）。治疗6个月后，过敏性哮喘组及过敏性鼻炎组血清sIgE水平均较治疗前有明显下降，而血清sIgG4水平却较治疗前明显上升，差异均有统计学意义（P＜0．01）。sIgE和sIgG4联合检测，对过敏性哮喘和过敏性鼻炎的诊断灵敏度分别为90．6％（77/85）和84．7％（61/72），诊断特异度分别为81．2％（69/85）和76．4％（55/72）。结论sIgE和sIgG4是反映过敏性疾病的良好指标。
目的：探討血清特異性IgE（sIgE）和特異性IgG4（sIgG4）檢測在兒童過敏性哮喘及過敏性鼻炎中的臨床應用價值。方法採用ELISA法對85例過敏性哮喘組患兒、72例過敏性鼻炎組患兒及60例對照組健康兒童血清中sIgE和sIgG4進行檢測。採用ROC麯線分析sIgE和sIgG4對過敏性哮喘和過敏性鼻炎的診斷效能。結果過敏性哮喘組和過敏性鼻炎組治療前血清sIgE和sIgG4水平均明顯高于對照組，差異有統計學意義（P＜0．01）。治療6箇月後，過敏性哮喘組及過敏性鼻炎組血清sIgE水平均較治療前有明顯下降，而血清sIgG4水平卻較治療前明顯上升，差異均有統計學意義（P＜0．01）。sIgE和sIgG4聯閤檢測，對過敏性哮喘和過敏性鼻炎的診斷靈敏度分彆為90．6％（77/85）和84．7％（61/72），診斷特異度分彆為81．2％（69/85）和76．4％（55/72）。結論sIgE和sIgG4是反映過敏性疾病的良好指標。
목적：탐토혈청특이성IgE（sIgE）화특이성IgG4（sIgG4）검측재인동과민성효천급과민성비염중적림상응용개치。방법채용ELISA법대85례과민성효천조환인、72례과민성비염조환인급60례대조조건강인동혈청중sIgE화sIgG4진행검측。채용ROC곡선분석sIgE화sIgG4대과민성효천화과민성비염적진단효능。결과과민성효천조화과민성비염조치료전혈청sIgE화sIgG4수평균명현고우대조조，차이유통계학의의（P＜0．01）。치료6개월후，과민성효천조급과민성비염조혈청sIgE수평균교치료전유명현하강，이혈청sIgG4수평각교치료전명현상승，차이균유통계학의의（P＜0．01）。sIgE화sIgG4연합검측，대과민성효천화과민성비염적진단령민도분별위90．6％（77/85）화84．7％（61/72），진단특이도분별위81．2％（69/85）화76．4％（55/72）。결론sIgE화sIgG4시반영과민성질병적량호지표。
Objective To explore the clinical application value of the detection of sIgE and sIgG4 in children with allergic asthma and allergic rhinitis .Methods The levels of sIgE and sIgG4 of allergic asthma group (n=85) ,allergic rhinitis group (n=72) and control group (n=60) were respectively detected by ELISA .The diagnostic efficiency of sIgE and sIgG4 were analyzed by using ROC curve .Results Before treatment ,the serum levels of sIgE and sIgG4 of allergic asthma group and allergic rhinitis group were remarkably higher than those of control group (P< 0 .01) .After 6 -month treatment ,the serum sIgE levels of allergic asthma group and allergic rhinitis group significantly decreased ,and the serum sIgG4 levels significantly increased (P< 0 .01) .For the combined detection of sIgE and sIgG4 ,the diagnostic sensitivities of allergic asthma and allergic rhinitis were 90 .6% (77/85) and 84 .7% (61/72) respectively ,and the diagnostic specificities of allergic asthma and allergic rhinitis were 81 .2% (69/85) and 76 .4%(55/72) respectively .Conclusion The serum sIgE and sIgG4 are good indicators for the diagnosis of allergic diseases .
