CAJ | 학술논문

目的：探讨幽门螺杆菌感染对血清同型半胱氨酸（Hcy）浓度的影响及其与冠心病（CHD）的关系。方法选取159例CHD患者作为研究对象，根据14C尿素呼气试验结果将患者分为感染组和非感染组；根据感染严重程度将CHD患者分为阴性组、轻度感染组、重度感染组。根据SYNTAX评分将感染幽门螺杆菌的CHD患者分为低危组、中危组、高危组。采用循环酶法测定各研究对象血清Hcy浓度。结果感染组血清Hcy浓度高于非感染组，差异有统计学意义（P＜0．01）。随着幽门螺杆菌感染程度的加重，血清Hcy浓度升高，阴性组、轻度感染组、重度感染组间比较，血清Hcy浓度差异有统计学意义（P＜0．01）。感染幽门螺杆菌的CHD患者随着冠状动脉病变严重程度的增加，其血清Hcy浓度也增加，低危组、中危组、高危组间比较，血清Hcy浓度差异有统计学意义（P＜0．01）。结论幽门螺杆菌感染可能通过升高血清Hcy浓度，在CHD的发生、发展中起作用。
목적：탐토유문라간균감염대혈청동형반광안산（Hcy）농도적영향급기여관심병（CHD）적관계。방법선취159례CHD환자작위연구대상，근거14C뇨소호기시험결과장환자분위감염조화비감염조；근거감염엄중정도장CHD환자분위음성조、경도감염조、중도감염조。근거SYNTAX평분장감염유문라간균적CHD환자분위저위조、중위조、고위조。채용순배매법측정각연구대상혈청Hcy농도。결과감염조혈청Hcy농도고우비감염조，차이유통계학의의（P＜0．01）。수착유문라간균감염정도적가중，혈청Hcy농도승고，음성조、경도감염조、중도감염조간비교，혈청Hcy농도차이유통계학의의（P＜0．01）。감염유문라간균적CHD환자수착관상동맥병변엄중정도적증가，기혈청Hcy농도야증가，저위조、중위조、고위조간비교，혈청Hcy농도차이유통계학의의（P＜0．01）。결론유문라간균감염가능통과승고혈청Hcy농도，재CHD적발생、발전중기작용。
Objective To investigate the infection of Helicobacter pylori infection on the serum concentration of homocysteine (Hcy) and its relationship with coronary heart disease (CHD) .Methods 159 cases of patients with CHD were selected as the re‐search subjects .They were divided into two groups :infection group and non‐infection group ,according to the results of 14 C‐urea breathe test .And they were also divided into three groups :negative group ,mild infection group and severe infestation group ,accord‐ing to the severity of infection .The CHD patients infected Helicobacter pylori were divided into three groups:low risk group ,mod‐erate risk group and high risk group ,according to SYNTAX scores .The serum Hcy concentration was determined by cyclic enzy‐matic method .Results Comparing with non‐infection group ,the serum Hcy concentration significantly increased in infection group (P<0 .01) .With the aggravation of Helicobacter pylori infection ,the serum Hcy concentration increased .There were significant difference among negative group ,mild infection group and severe infestation group (P<0 .01) .In the CHD patients infected Heli‐cobacter pylori ,the serum Hcy concentration also increased with the aggravation of the severity of coronary lesion .And there were significant difference among low risk group ,moderate risk group and high risk group (P<0 .01) .Conclusion Helicobacter pylori plays a role in the incidence and development of CHD through increasing the serum Hcy concentration .