CAJ | 학술논문

目的：研究妊娠合并乙型肝炎病毒感染孕妇母婴垂直传播相关因素。方法选择妊娠合并乙型肝炎病毒感染孕妇100例作为研究对象，对患者病病历资料作回顾性分析。结果HBsAg单阳性孕妇母婴垂直传播几率1.75%较HBsAg、HBeAg双阳性母婴垂直传播几率46.51%低，差异有统计学意义(P<0.05)。外周血HBV DNA≥106copies/mL的产孕妇分娩后胎儿HBV DNA阳性率50.0%较HBV DNA≤105copies/mL和105copies/mL<HBV DNA<106copies/mL组高，差异有统计学意义(P<0.05)。结论母血中HBsAg单阳性、HBsAg/HBeAg双阳性以及高载量HBV DNA与宫内感染存在直接关系。
목적：연구임신합병을형간염병독감염잉부모영수직전파상관인소。방법선택임신합병을형간염병독감염잉부100례작위연구대상，대환자병병력자료작회고성분석。결과HBsAg단양성잉부모영수직전파궤솔1.75%교HBsAg、HBeAg쌍양성모영수직전파궤솔46.51%저，차이유통계학의의(P<0.05)。외주혈HBV DNA≥106copies/mL적산잉부분면후태인HBV DNA양성솔50.0%교HBV DNA≤105copies/mL화105copies/mL<HBV DNA<106copies/mL조고，차이유통계학의의(P<0.05)。결론모혈중HBsAg단양성、HBsAg/HBeAg쌍양성이급고재량HBV DNA여궁내감염존재직접관계。
Objective To investigate the relative factors of mother-to-infant vertical transmission of hepatitis B virus. Methods 100 pregnant women with hepatitis B virus infection were selected as the subjects. And the medical records of them were analyzed retrospectively. Results The probability of mother-to-infant vertical transmission of the pregnant women with positive HBsAg was 1.75%, lower than 46.51% of the pregnant women with double positive HBsAg, HBeAg, the difference was statistically significant (P<0.05). The fetal HBV DNA positive rate of the pregnant women with HBV DNA ≥ 106copies/ml in peripheral blood after childbirth was 50.0%, higher than HBV DNA≤105copies/ml and 105copies/ml <HBV DNA <106copies/ml group, the difference was statistically significant (P<0.05). Conclusion HBsAg single positive, HBsAg/HBeAg double positive and high load HBV DNA in the maternal blood are directly related to intrauterine infection.