中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
27期
44-45,68
,共3页
肺腺癌%恶性胸膜间皮瘤%免疫组化%诊断
肺腺癌%噁性胸膜間皮瘤%免疫組化%診斷
폐선암%악성흉막간피류%면역조화%진단
Lung adenocarcinoma%Malignant pleural mesothelioma%Immunohistochemistry%Diagnosis
目的：探讨免疫组化检查对于恶性胸膜间皮瘤与肺腺癌的诊断鉴别作用。方法收集恶性胸膜间皮瘤患者17例以及肺腺癌患者33例，采用免疫组化EnVision二步法进行检测，比较两种疾病患者的免疫组化检查结果。结果恶性胸膜间皮瘤的 CD141、WT1、calretinin、EMA、CK5/6、B72.3、Ber-EP4、AE1/AE3、CEA 的表达±次为82.4%、58.8%、58.8%、58.8%、64.7%、0.0%、5.9%、82.4%、0.0%，与肺腺癌的3.0%、9.1%、0.0%、97.0%、9.1%、72.7%、63.6%、100.0%、90.9%比较差异有统计学意义(P<0.05)，两种病变间Moc-31与HBME-1表达差异无统计学意义(P>0.05)。结论免疫组化检查对于恶性胸膜间皮瘤与肺腺癌的诊断鉴别具有重要意义，以calretinin、CD141、WT-1、CEA与B72.3的敏感性与特异性最高。
目的：探討免疫組化檢查對于噁性胸膜間皮瘤與肺腺癌的診斷鑒彆作用。方法收集噁性胸膜間皮瘤患者17例以及肺腺癌患者33例，採用免疫組化EnVision二步法進行檢測，比較兩種疾病患者的免疫組化檢查結果。結果噁性胸膜間皮瘤的 CD141、WT1、calretinin、EMA、CK5/6、B72.3、Ber-EP4、AE1/AE3、CEA 的錶達±次為82.4%、58.8%、58.8%、58.8%、64.7%、0.0%、5.9%、82.4%、0.0%，與肺腺癌的3.0%、9.1%、0.0%、97.0%、9.1%、72.7%、63.6%、100.0%、90.9%比較差異有統計學意義(P<0.05)，兩種病變間Moc-31與HBME-1錶達差異無統計學意義(P>0.05)。結論免疫組化檢查對于噁性胸膜間皮瘤與肺腺癌的診斷鑒彆具有重要意義，以calretinin、CD141、WT-1、CEA與B72.3的敏感性與特異性最高。
목적：탐토면역조화검사대우악성흉막간피류여폐선암적진단감별작용。방법수집악성흉막간피류환자17례이급폐선암환자33례，채용면역조화EnVision이보법진행검측，비교량충질병환자적면역조화검사결과。결과악성흉막간피류적 CD141、WT1、calretinin、EMA、CK5/6、B72.3、Ber-EP4、AE1/AE3、CEA 적표체±차위82.4%、58.8%、58.8%、58.8%、64.7%、0.0%、5.9%、82.4%、0.0%，여폐선암적3.0%、9.1%、0.0%、97.0%、9.1%、72.7%、63.6%、100.0%、90.9%비교차이유통계학의의(P<0.05)，량충병변간Moc-31여HBME-1표체차이무통계학의의(P>0.05)。결론면역조화검사대우악성흉막간피류여폐선암적진단감별구유중요의의，이calretinin、CD141、WT-1、CEA여B72.3적민감성여특이성최고。
Objective To investigate the role of immunohistochemical examination in the differential diagnosis of malignant pleural mesothelioma and lung adenocarcinoma. Methods 17 cases of patients with malignant pleural mesothelioma and 33 cases with lung adenocarcinoma were collected. Immunohistochemical EnVision two steps method was used for detection. And the immunohis-tochemical results of the two groups were compared. Results The expression of CD141, WT1, calretinin, EMA, CK5/6, B72.3, Ber-EP4, AE1/AE3, CEA in malignant pleural mesothelioma was 82.4%, 58.8%, 58.8%, 58.8%, 64.7%, 0.0%, 5.9%, 82.4%, 0.0%, re-spectively, and that in lung adenocarcinoma was 3.0%, 9.1%, 0.0%, 97.0%, 9.1%, 72.7%, 63.6%, 100.0%, 90.9%, respectively. There was significant difference between the two groups (P<0.05). The expression of Moc-31 and HBME-1 between the two groups had no significant difference (P>0.05). Conclusion Immunohistochemical examination plays an important role in the differential di-agnosis of malignant pleural mesothelioma and lung adenocarcinoma, the sensitivity and specificity of calretinin, CD141, WT-1, CEA and B72.3 are the highest.
