中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
27期
8-10
,共3页
非杓性高血压%替米沙坦%给药时间%疗效%不良反应
非杓性高血壓%替米沙坦%給藥時間%療效%不良反應
비표성고혈압%체미사탄%급약시간%료효%불량반응
Non-dipper hypertension%Telmisartan%Administration time%Efficacy%Adverse reactions
目的：探讨分析替米沙坦在不同的时间点给药治疗非杓性高血压患者的疗效及不良反应。方法严格筛选170例轻、中度的非杓型高血压患者，按照随机数字表法随机分为晨服药组(83例)、晚服药组(87例)，两组患者均给予相同剂量的替米沙坦(血管紧张素Ⅱ受体拮抗剂)进行治疗。晨服组是于早上8点一次性给予患者80 mg的替米沙坦；晚服药组是于夜8点一次性给予患者80 mg的替米沙坦，两组患者服药频率均为1次/d。连续给药12周后检测两组患者的动态血压来衡量患者昼夜血压节律的差异。结果两个实验组都有患者由非杓性高血压逐渐转变为杓性高血压，晨服药组的转变率为21%，晚服药组的转变率为53%，且两组之间差异有统计学意义(P<0.05)。两组患者在服用替米沙坦期间都出现了不良反应，但不良反应轻微，无需进行特殊的治疗，两组之间不良反应的发生率差异无统计学意义。结论该研究表明替米沙坦能够显著地治疗非杓性高血压，且在晚间服用药物的效果更佳，为临床用药时间的选择提供有效的参考。
目的：探討分析替米沙坦在不同的時間點給藥治療非杓性高血壓患者的療效及不良反應。方法嚴格篩選170例輕、中度的非杓型高血壓患者，按照隨機數字錶法隨機分為晨服藥組(83例)、晚服藥組(87例)，兩組患者均給予相同劑量的替米沙坦(血管緊張素Ⅱ受體拮抗劑)進行治療。晨服組是于早上8點一次性給予患者80 mg的替米沙坦；晚服藥組是于夜8點一次性給予患者80 mg的替米沙坦，兩組患者服藥頻率均為1次/d。連續給藥12週後檢測兩組患者的動態血壓來衡量患者晝夜血壓節律的差異。結果兩箇實驗組都有患者由非杓性高血壓逐漸轉變為杓性高血壓，晨服藥組的轉變率為21%，晚服藥組的轉變率為53%，且兩組之間差異有統計學意義(P<0.05)。兩組患者在服用替米沙坦期間都齣現瞭不良反應，但不良反應輕微，無需進行特殊的治療，兩組之間不良反應的髮生率差異無統計學意義。結論該研究錶明替米沙坦能夠顯著地治療非杓性高血壓，且在晚間服用藥物的效果更佳，為臨床用藥時間的選擇提供有效的參攷。
목적：탐토분석체미사탄재불동적시간점급약치료비표성고혈압환자적료효급불량반응。방법엄격사선170례경、중도적비표형고혈압환자，안조수궤수자표법수궤분위신복약조(83례)、만복약조(87례)，량조환자균급여상동제량적체미사탄(혈관긴장소Ⅱ수체길항제)진행치료。신복조시우조상8점일차성급여환자80 mg적체미사탄；만복약조시우야8점일차성급여환자80 mg적체미사탄，량조환자복약빈솔균위1차/d。련속급약12주후검측량조환자적동태혈압래형량환자주야혈압절률적차이。결과량개실험조도유환자유비표성고혈압축점전변위표성고혈압，신복약조적전변솔위21%，만복약조적전변솔위53%，차량조지간차이유통계학의의(P<0.05)。량조환자재복용체미사탄기간도출현료불량반응，단불량반응경미，무수진행특수적치료，량조지간불량반응적발생솔차이무통계학의의。결론해연구표명체미사탄능구현저지치료비표성고혈압，차재만간복용약물적효과경가，위림상용약시간적선택제공유효적삼고。
Objective To investigate and analyze the efficacy and adverse reactions of telmisartan administered at different time points for the treatment of patients with non-dipper hypertension. Methods 170 cases with mild or moderate non-dipper hypertension were selected strictly and randomly divided into the morning medication group (83 cases) and evening medication group (87 cases). Both groups were given the same dose of telmisartan (angiotensin II receptor antagonist) once a day for treatment, the morning medication group was given telmisartan 80mg at eight in the morning, and the evening medication group was given telmisartan 80mg at eight in the evening. The ambulatory blood pressure of the two groups of patients were monitored after 12 weeks of continuous administration for assessing the difference in circadian blood pressure rhythm. Results Both groups had patients with non-dipper hypertension transforming into dipper hypertension, the number turnover of the morning medication group was 21%, and that of the evening medication group was 53%, the difference between the two groups was statistically significant (P<0.05). Both groups of patients suffered mild adverse reactions during the period of taking telmisartan but needed not special treatment. And there was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion This study indicates that telmisartan can treat non-dipper hypertension with significant effect, and the curative effect will be better if it is administered in the evening, which can provide an effective reference for selecting the time of medication clinically.
