CAJ | 학술논문

目的：了解未分化关节炎（undifferentiated arthritis，UA）的抗CCP检测情况及发展规律。方法分析162例UA患者抗CCP检测情况及3年随访结果。结果①首诊检测抗CCP抗体阳性率为4.3%；②病程中双手近端指间及足腕关节疼痛最多见；③3年随访结果：42例仍为UA，58例症状消失；另外62例转归为类风湿关节炎（RA）、骨性关节炎（OA）、强直性脊柱炎（AS）、系统性红斑狼疮（SLE)；④3年内抗CCP检测阳性率上升明显，3年后上升为14.8%；⑤3年中抗CCP抗体阳性患者全部确诊RA，RA患者抗CCP抗体阳性率52.2%。结论 UA是一组常见的关节炎,部分患者可进展为RA、OA、AS及SLE等其他疾病。对UA患者应定期进行抗CCP抗体检测，有助于类风湿关节炎的早期诊断。
목적：료해미분화관절염（undifferentiated arthritis，UA）적항CCP검측정황급발전규률。방법분석162례UA환자항CCP검측정황급3년수방결과。결과①수진검측항CCP항체양성솔위4.3%；②병정중쌍수근단지간급족완관절동통최다견；③3년수방결과：42례잉위UA，58례증상소실；령외62례전귀위류풍습관절염（RA）、골성관절염（OA）、강직성척주염（AS）、계통성홍반랑창（SLE)；④3년내항CCP검측양성솔상승명현，3년후상승위14.8%；⑤3년중항CCP항체양성환자전부학진RA，RA환자항CCP항체양성솔52.2%。결론 UA시일조상견적관절염,부분환자가진전위RA、OA、AS급SLE등기타질병。대UA환자응정기진행항CCP항체검측，유조우류풍습관절염적조기진단。
Objective To investigate the determination of anti-CCP and the law of development of undifferentiated arthritis (UA). Methods 162 UA patients were registered in rheumatology outpatient clinic of Jincheng People's Hospital. The determination results of anti-CCP and 3-year follow-up data of them were collected and analyzed. Results ①4.3%were anti-CCP positive in the initial diagnosis.②The chief symptoms of 162 UA patients were hands proximal interphalangeal pain and foot wrist pain. ③In three years 162 cases developed to 46 cases rheumatoid arthritis(RA),8 osteoarthritis(OA),5 ankylosing spondylitis(AS),3 systemic lupus erythematosus(SLE),42 UA,58 cases with symptomatic disappeared.④In 3 years the positive rates of anti-CCP had dramatically increased, and reached to 14.8%after 3-year follow-up. ⑤In three years, the anti-CCP positive patients all have been confirmed RA, and the positive rates of anti-CCP of RA was 52.2%. Conclusion UA were a group of a variety of arthritis, some patients can progress to RA, OA, AS and SLE, and other rheumatism. Close follow-up on the patients, especially anti-CCP positive patients, and regular anti-CCP determination conduce to early diagnosis of RA.