CAJ | 학술논문

目的：探讨莫沙必利联合不同胃酸分泌抑制剂类药物对反流性食管炎（RE）的影响。方法将116例RE患者随机分为治疗组和对照组，治疗组给予莫沙必利片+泮托拉唑肠溶胶囊，对照组予莫沙必利片+法莫替丁，观察2组患者症状改善、消失时间以及临床疗效。结果治疗组症状改善时间和消失时间均明显短于对照组（P<0.01），症状和胃镜下显效率均优于对照组，差异均有统计学意义（P<0.05）。结论胃肠动力药莫沙比利联合质子泵抑制剂药物泮托拉唑对RE的作用强于联合H2受体拮抗剂类药物法莫替丁。
목적：탐토막사필리연합불동위산분비억제제류약물대반류성식관염（RE）적영향。방법장116례RE환자수궤분위치료조화대조조，치료조급여막사필리편+반탁랍서장용효낭，대조조여막사필리편+법막체정，관찰2조환자증상개선、소실시간이급림상료효。결과치료조증상개선시간화소실시간균명현단우대조조（P<0.01），증상화위경하현효솔균우우대조조，차이균유통계학의의（P<0.05）。결론위장동력약막사비리연합질자빙억제제약물반탁랍서대RE적작용강우연합H2수체길항제류약물법막체정。
Objective To investigate the effect of Mosapride combined with different gastric acid secretion inhibitors on reflux esophagitis (RE). Methods 116 cases of RE were randomly divided into treatment group and control group,treatment group was treated with Mosapride + Pantoprazole,the control group was given Mosapride +Famotidine,symptoms improved and disappeared time and clinical effect of two groups were observed. Results In treatment group,the time of symptoms improved and disappeared was shorter than the control group (P<0.01),clinical symptoms effect and endoscopic effect was better than the control group,The difference between two groups was significant(P<0.05).Conclusion The effect of gastrointestinal motility Mosapride combined with proton pump inhibitor Pantoprazole was stronger on RE than combined with H 2 receptor antagonists' Famotidine.