CAJ | 학술논문

中药丹参的活性成分丹参素是一种化学结构简单但特殊，并具有广泛的生理药理学活性的有机小分子化合物，丹参素类药物在抗心肌缺血和保肝护肝等方面疗效显著。然而，仅依靠从丹参中分离得到丹参素(或其衍生物)远不能满足临床需要。依靠化学方法简洁、高效的合成丹参素(或其衍生物)是该类药物研发亟须解决的问题之一。综述了近年来国内外相关报道，对外消旋体和光学纯丹参素的合成路线进行讨论，并就其构效关系进行初步分析；其中，光学纯丹参素的简单、高效、高选择性合成仍然是药物化学和有机化学关注的重点。新的合成方法和有关丹参素详细的构效关系研究，对开发丹参素类药物具有重要意义。
중약단삼적활성성분단삼소시일충화학결구간단단특수，병구유엄범적생리약이학활성적유궤소분자화합물，단삼소류약물재항심기결혈화보간호간등방면료효현저。연이，부의고종단삼중분리득도단삼소(혹기연생물)원불능만족림상수요。의고화학방법간길、고효적합성단삼소(혹기연생물)시해류약물연발극수해결적문제지일。종술료근년래국내외상관보도，대외소선체화광학순단삼소적합성로선진행토론，병취기구효관계진행초보분석；기중，광학순단삼소적간단、고효、고선택성합성잉연시약물화학화유궤화학관주적중점。신적합성방법화유관단삼소상세적구효관계연구，대개발단삼소류약물구유중요의의。
Danshensu,the active component of Danshen,is a kind of organic compound with simple but particular chemical structure,and widespread physiological and pharmacological activities,es-pecially in the anti-myocardial ischemia and liver protection.However,the sources of Danshensu (or its derivatives)which are isolated from Danshen are limited and could not satisfied the clini-cal need.Therefore,how to synthesis Danshensu(or its derivatives)simply and effectively using chemical methods is the crucial problem needing to be solved during the process of drug develop-ment.In the essay,the relative reports in recent years were reviewed and the synthesis pathway for racemic body and optic pure danshensu were discussed,the structure-function relationship were primarily analyzed,among them,how to synthesis optic pure danshensu using simply,high effective and selective method remain to be the focus of medical chemistry and organic chemis-try.The study regarding novel synthesis methods and detailed exploration of structure-function relationship would provide basis for the development of Danshensu-like drugs.