临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014年
21期
1781-1782,1783
,共3页
老年人%肺癌%贫血%促红细胞生成素%安全性
老年人%肺癌%貧血%促紅細胞生成素%安全性
노년인%폐암%빈혈%촉홍세포생성소%안전성
Elderly%Lung cancer%Anemia%Erythropoietin%Safety
目的：观察促红细胞生成素（ EPO）对老年肺癌贫血的治疗效果并评价其治疗安全性。方法以2011年5月至2013年6月收治的肺癌合并贫血的36例老年患者为研究对象，按随机数字表格法分为两组。对照组18例患者给予蔗糖铁注射液，观察组在对照组基础上加用EPO，两组在对症处理与营养支持上相同，且均不放化疗，治疗6周后比较两组疗效。结果治疗后两组患者的红细胞数、血红蛋白数及血细胞比容值均较治疗前明显升高（ P <0.05）；观察组治疗后上述3个指标均明显高于采用对照组[（4.27℃0.38）×1012/L vs.（3.53℃0.42）×1012/L，（115.12℃5.47）g/L vs.（95.64℃5.66）g/L，（36.54℃4.38）% vs.（31.41℃3.13）%，均P <0.05]；观察组的总有效率94.44%也明显高于对照组的77.78%（ P <0.05）。结论 EPO治疗老年肺癌贫血安全有效，建议在治疗过程中对患者进行血压监测。
目的：觀察促紅細胞生成素（ EPO）對老年肺癌貧血的治療效果併評價其治療安全性。方法以2011年5月至2013年6月收治的肺癌閤併貧血的36例老年患者為研究對象，按隨機數字錶格法分為兩組。對照組18例患者給予蔗糖鐵註射液，觀察組在對照組基礎上加用EPO，兩組在對癥處理與營養支持上相同，且均不放化療，治療6週後比較兩組療效。結果治療後兩組患者的紅細胞數、血紅蛋白數及血細胞比容值均較治療前明顯升高（ P <0.05）；觀察組治療後上述3箇指標均明顯高于採用對照組[（4.27℃0.38）×1012/L vs.（3.53℃0.42）×1012/L，（115.12℃5.47）g/L vs.（95.64℃5.66）g/L，（36.54℃4.38）% vs.（31.41℃3.13）%，均P <0.05]；觀察組的總有效率94.44%也明顯高于對照組的77.78%（ P <0.05）。結論 EPO治療老年肺癌貧血安全有效，建議在治療過程中對患者進行血壓鑑測。
목적：관찰촉홍세포생성소（ EPO）대노년폐암빈혈적치료효과병평개기치료안전성。방법이2011년5월지2013년6월수치적폐암합병빈혈적36례노년환자위연구대상，안수궤수자표격법분위량조。대조조18례환자급여자당철주사액，관찰조재대조조기출상가용EPO，량조재대증처리여영양지지상상동，차균불방화료，치료6주후비교량조료효。결과치료후량조환자적홍세포수、혈홍단백수급혈세포비용치균교치료전명현승고（ P <0.05）；관찰조치료후상술3개지표균명현고우채용대조조[（4.27℃0.38）×1012/L vs.（3.53℃0.42）×1012/L，（115.12℃5.47）g/L vs.（95.64℃5.66）g/L，（36.54℃4.38）% vs.（31.41℃3.13）%，균P <0.05]；관찰조적총유효솔94.44%야명현고우대조조적77.78%（ P <0.05）。결론 EPO치료노년폐암빈혈안전유효，건의재치료과정중대환자진행혈압감측。
Objective To observe the efficacy of erythropoietin( EPO)in treatment of anemia in elderly patients with lung cancer and to evaluate the safety of treatment. Methods A total of 36 elderly patients with lung cancer associated with anemia admitted to this hospital during May 2011 to June 2013 were randomly divided into two groups according to the random table method. 18 patients in control group were treated with iron sucrose injection,and patients in observation group were treated with EPO on the basic treatment in control group,patients in these two groups had the same symptomatic treatment and nutritional support,and the efficacy of both of them were compared after chemotherapy for 6 weeks. Re-sults After treatment,the red blood cell count,hemoglobin count and hematocrit value of these patients were significantly elevated than those be-fore treatment( P <0. 05),and the three indexes were significantly higher than those of control group[(4. 27℃0. 38) × 1012/L vs.(3. 53℃0. 42) × 1012/L,(115. 12℃5. 47)g/ L vs.(95. 64℃5. 66)g/L,(36. 54℃4. 38)% vs.(31. 41℃3. 13)%,both P <0. 05]. The total ef-fective rate in observation group was 94. 44% and it was significantly higher than that(77. 78%)of control group( P <0. 05). Conclusion The treatment with EPO in elderly patients with lung cancer associated with anemia is safe and effective,and it is recommended to monitor the blood pressure of patients during the course of treatment.
