CAJ | 학술논문

目的：研究应用高压氧治疗突发性耳聋的最优方案与预后。方法57例（70耳）突发性耳聋患者均进行高压氧治疗，根据患者病时的不同情况（年龄、患病天数，就诊时听力损失，高压氧治疗疗程）等进行分组分析。结果由单因素相关分析结果可知，治疗效果随患者年龄增大而明显降低，其中以9~19岁患者就诊时总体治疗效果最佳；此外，就诊时间及就诊时听力损失程度也在一定程度上影响患者后期治疗效果，且由Spearman相关系数显示，两者均与治疗效果呈负相关；随着高压氧治疗时间增加，患者治疗有效率也明显增加，但超过24个疗程时，其有效率迅速降低；同时，若合并有眩晕症状患者其治疗效果明显低于无次症状患者（ P <0.01）。而经多因素Logistic分析可知，如年龄、就诊时间、就诊时听力损伤程度、高压氧疗程及是否伴有眩晕均可影响患者预后情况。结论突发性耳聋患者采取早诊断、早治疗及合理使用高压氧的疗法及次数可有效提高患者预后治疗效果，但在治疗过程中，仍需考虑患者治疗前的听力损失程度及是否伴有眩晕等症状。
목적：연구응용고압양치료돌발성이롱적최우방안여예후。방법57례（70이）돌발성이롱환자균진행고압양치료，근거환자병시적불동정황（년령、환병천수，취진시은력손실，고압양치료료정）등진행분조분석。결과유단인소상관분석결과가지，치료효과수환자년령증대이명현강저，기중이9~19세환자취진시총체치료효과최가；차외，취진시간급취진시은력손실정도야재일정정도상영향환자후기치료효과，차유Spearman상관계수현시，량자균여치료효과정부상관；수착고압양치료시간증가，환자치료유효솔야명현증가，단초과24개료정시，기유효솔신속강저；동시，약합병유현훈증상환자기치료효과명현저우무차증상환자（ P <0.01）。이경다인소Logistic분석가지，여년령、취진시간、취진시은력손상정도、고압양료정급시부반유현훈균가영향환자예후정황。결론돌발성이롱환자채취조진단、조치료급합리사용고압양적요법급차수가유효제고환자예후치료효과，단재치료과정중，잉수고필환자치료전적은력손실정도급시부반유현훈등증상。
Objective To find the best regimen of hyperbaric oxygen( HBO)in treatment of patients with sudden deafness( SD). Meth-ods A total of 57 patients(70 ears)with sudden deafness were treated with HBO and they were divided into different groups for analysis of their conditions such as the duration of illness,the severity of hearing loss at consulting physicians,the course of HBO and so on. Results The results of single factor correlation analysis showed that effect of treatment was significantly decreased following the increase of age of patients,it was the best in patients with 9~19 years old. Furthermore,the degree of hearing loss,the time for diagnosis and duration of treatment were also in some extent affected the effect of treatment,and the result of Spearman correlation coefficients showed that both were negatively correlated with the thera-peutic effect,and this study also found that following the increase of times for hyperbaric oxygen therapy,the efficiency of treatment was also signif-icantly increased,but if the treatment was taken more than 24 courses,its efficiency would be rapidly decreased. If it associated with symptoms of vertigo,then its therapeutic effect would be significantly lowered than those patients without secondary symptoms( P <0. 01). The Multivariate Logistic analysis showed that age,time for consultation to physicians,the degree of hearing loss,the course of hyperbaric oxygen treatment and the association with vertigo can affect the prognosis of patients. Conclusion Patients with sudden deafness should be early diagnosed and treated,and the frequency of rational application of hyperbaric oxygen therapy can effectively improve the prognosis of patients,but during the course of treat-ment,it still need to consider the degree of hearing loss of patients before treatment and whether it associate with dizziness and other symptoms.