现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
22期
3385-3387
,共3页
糖蛋白类%脓毒症%炎症%降钙素%死亡率%预后
糖蛋白類%膿毒癥%炎癥%降鈣素%死亡率%預後
당단백류%농독증%염증%강개소%사망솔%예후
Glycoproteins%Sepsis%Inflammation%Calcitonin%Mortality%Prognosis
目的：探讨乌司他丁对脓毒症患者降钙素原（PCT）水平的影响及临床意义。方法将2013年3~12月收治的60例脓毒症患者随机分为治疗组（31例）和对照组（29例），治疗组给予注射用乌司他丁1万U/（kg·d），对照组给予同等剂量生理盐水，均24h持续静脉微量泵入，连续7d。两组患者均于用药前1d和用药7d后清晨抽取外周血检测PCT水平，并观察28 d住院病死率。结果治疗组用药7 d后PCT水平低于同期对照组，28 d住院病死率低于对照组，差异均有统计学意义（P<0.05）。结论乌司他丁能降低脓毒症患者体内PCT水平，拮抗炎性反应，降低28 d住院病死率。
目的：探討烏司他丁對膿毒癥患者降鈣素原（PCT）水平的影響及臨床意義。方法將2013年3~12月收治的60例膿毒癥患者隨機分為治療組（31例）和對照組（29例），治療組給予註射用烏司他丁1萬U/（kg·d），對照組給予同等劑量生理鹽水，均24h持續靜脈微量泵入，連續7d。兩組患者均于用藥前1d和用藥7d後清晨抽取外週血檢測PCT水平，併觀察28 d住院病死率。結果治療組用藥7 d後PCT水平低于同期對照組，28 d住院病死率低于對照組，差異均有統計學意義（P<0.05）。結論烏司他丁能降低膿毒癥患者體內PCT水平，拮抗炎性反應，降低28 d住院病死率。
목적：탐토오사타정대농독증환자강개소원（PCT）수평적영향급림상의의。방법장2013년3~12월수치적60례농독증환자수궤분위치료조（31례）화대조조（29례），치료조급여주사용오사타정1만U/（kg·d），대조조급여동등제량생리염수，균24h지속정맥미량빙입，련속7d。량조환자균우용약전1d화용약7d후청신추취외주혈검측PCT수평，병관찰28 d주원병사솔。결과치료조용약7 d후PCT수평저우동기대조조，28 d주원병사솔저우대조조，차이균유통계학의의（P<0.05）。결론오사타정능강저농독증환자체내PCT수평，길항염성반응，강저28 d주원병사솔。
Objective To explore the curative effect and clinical significance of ulinastatin on procalcitonin (PCT) in patients with sepsis. Methods A total of 60 patients with sepsis,who were received from March to December of 2013,were ran-domly divided into treatment group(n=31) and control group(n=29). The treatment group was injected with ulinastatin with the dosage of 10 000 U/(kg·d),while the control group received normal saline with the same dose of the treatment group,24 h con-tinuously intravenous macro-pump for 7 d. Peripheral blood was withdrawn in both groups 1 d before administration and 7 d after administration to measure the PCT level,and the 28 d hospital fatality rate was observed. Results The PCT level 7 d after admin-istration in the treatment group was lower than that in the control group in the same period ,and the 28 d hospital fatality rate in the treatment group was lower than that in the control group, the differences between the two groups all had statistical significance(P<0.05). Conclusion Ulinastatin can reduce PCT level in patients with sepsis,inhibit inflammation response and decrease 28 d hospital fatality rate.
