现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
22期
3381-3382
,共2页
比索洛尔%慢性病%心力衰竭%血压%步行%坎地沙坦
比索洛爾%慢性病%心力衰竭%血壓%步行%坎地沙坦
비색락이%만성병%심력쇠갈%혈압%보행%감지사탄
Bisoprolol%Chronic disease%Heart failure%Blood pressure%Walking%Candesartan
目的：观察比索洛尔联合坎地沙坦治疗慢性心力衰竭（CHF）的疗效。方法选择该院2010年1月至2013年12月诊断为CHF患者136例，随机分为对照组和治疗组各68例。对照组患者常规应用利尿剂、洋地黄制剂等，治疗组患者在常规治疗基础上用比索洛尔和坎地沙坦治疗，疗程为6个月。观察两组患者治疗有效率和治疗前后心率、左室舒张末期内径、左室射血分数和6 min步行距离。结果治疗组总有效率[88.2%（60/68）]明显高于对照组[58.8%（40/68）]，差异有统计学意义（P<0.01）。治疗组在改善心功能方面优于对照组，差异有统计学意义（P<0.05）。两组患者治疗后的心率、左室舒张末期内径、左室射血分数和6 min步行距离比较，差异均有统计学意义（P<0.05）；两组患者病死率比较，差异有统计学意义（P<0.01）；治疗组未见明显不良反应。结论比索洛尔联合坎地沙坦治疗CHF安全有效，可提高运动耐受，降低患者再住院率和病死率。
目的：觀察比索洛爾聯閤坎地沙坦治療慢性心力衰竭（CHF）的療效。方法選擇該院2010年1月至2013年12月診斷為CHF患者136例，隨機分為對照組和治療組各68例。對照組患者常規應用利尿劑、洋地黃製劑等，治療組患者在常規治療基礎上用比索洛爾和坎地沙坦治療，療程為6箇月。觀察兩組患者治療有效率和治療前後心率、左室舒張末期內徑、左室射血分數和6 min步行距離。結果治療組總有效率[88.2%（60/68）]明顯高于對照組[58.8%（40/68）]，差異有統計學意義（P<0.01）。治療組在改善心功能方麵優于對照組，差異有統計學意義（P<0.05）。兩組患者治療後的心率、左室舒張末期內徑、左室射血分數和6 min步行距離比較，差異均有統計學意義（P<0.05）；兩組患者病死率比較，差異有統計學意義（P<0.01）；治療組未見明顯不良反應。結論比索洛爾聯閤坎地沙坦治療CHF安全有效，可提高運動耐受，降低患者再住院率和病死率。
목적：관찰비색락이연합감지사탄치료만성심력쇠갈（CHF）적료효。방법선택해원2010년1월지2013년12월진단위CHF환자136례，수궤분위대조조화치료조각68례。대조조환자상규응용이뇨제、양지황제제등，치료조환자재상규치료기출상용비색락이화감지사탄치료，료정위6개월。관찰량조환자치료유효솔화치료전후심솔、좌실서장말기내경、좌실사혈분수화6 min보행거리。결과치료조총유효솔[88.2%（60/68）]명현고우대조조[58.8%（40/68）]，차이유통계학의의（P<0.01）。치료조재개선심공능방면우우대조조，차이유통계학의의（P<0.05）。량조환자치료후적심솔、좌실서장말기내경、좌실사혈분수화6 min보행거리비교，차이균유통계학의의（P<0.05）；량조환자병사솔비교，차이유통계학의의（P<0.01）；치료조미견명현불량반응。결론비색락이연합감지사탄치료CHF안전유효，가제고운동내수，강저환자재주원솔화병사솔。
Objective To observe the clinical efficacy of bisoprolol combined with candesartan on congestive heart failure (CHF). Methods A total of 136 CHF patients in the hospital were selected from January 2010 to December 2013,and randomly divided into control group and treatment group, 68 cases in each group. The control group was conventionally treated with diuret-ics,digitalis preparation and so on,while the control group was added with bisoprolol and candesartan for treatment on the basis of the control group,6 months as a course. The heart rate,left ventricular end diastolic diameter (LVEDD),left ventricular ejection fraction(LVEF) and 6-minute walking distance in the two groups before and after treatment were observed. Results The total ef-fective rate in the treatment group [88.2%(60/68)] was obviously higher than that in the control group[58.8%(40/68)] with statis-tically significant difference(P<0.01). The improvement of cardiac function in the treatment group was better than that in the control group with statistically significant difference(P<0.05). The pairwise comparison between the two groups on heart rate,LVED、LVEF、6-minute walking distance all had statistically significant difference(P<0.05). There was statistically significant difference between the two groups on death rate(P<0.01);there was no obvious adverse reaction in the treatment group. Conclusion The combination of bisoprolol and candesartan is a safe and effective method for CHF,which can improve exercise tolerance,reduce hospitalization rate and death rate.
