现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
22期
3379-3380
,共2页
张劼%林鹭平%林志华%吴清秀%兰巧珍
張劼%林鷺平%林誌華%吳清秀%蘭巧珍
장할%림로평%림지화%오청수%란교진
半胱氨酸%糖尿病肾病%血清学%白蛋白类%血尿素氮
半胱氨痠%糖尿病腎病%血清學%白蛋白類%血尿素氮
반광안산%당뇨병신병%혈청학%백단백류%혈뇨소담
Cysteine%Diabetic nephropathies%Serology%Albumins%Blood urea nitrogen
目的:探讨同型半胱氨酸(Hcy)水平在2型糖尿病肾病发展中的变化及意义。方法随机选取该院2013年1~12月住院治疗的124例2型糖尿病患者,根据尿微量清蛋白与尿肌酐比值(UACR)分为四组:(1)糖尿病非肾病组(DM组,UACR<30 mg/g)30例;(2)早期糖尿病肾病组(DN1组,UACR 30~300 mg/g)26例;(3)临床糖尿病肾病组[DN2组,UACR>300 mg/g,血清肌酐(SCr)<133μmol/L]36例;(4)糖尿病肾病慢性肾功能衰竭组(DN3组,UACR>300 mg/g,SCr≥133μmol/L)32例。测定血清Hcy、SCr、BUN及糖化血红蛋白(HbA1c)水平,并对检测结果进行统计分析。结果四组检测指标结果比较,Hcy、SCr、BUN水平均随着疾病的严重程度呈升高趋势。Hcy水平在DM组和DN1组、DN2组、DN3组间比较,差异均有统计学意义(P<0.05)。血清Hcy与UACR水平呈正相关(r=0.546,P<0.05),SCr水平与Hcy呈正相关(r=0.361,P<0.05),HbA1c水平与Hcy呈负相关(r=-0.203,P<0.05)。结论 Hcy高水平可能是2型糖尿病肾病进展的危险因素之一,与2型糖尿病肾病的发生、发展具有密切关系,可作为2型糖尿病肾病早期诊断的临床检测指标。
目的:探討同型半胱氨痠(Hcy)水平在2型糖尿病腎病髮展中的變化及意義。方法隨機選取該院2013年1~12月住院治療的124例2型糖尿病患者,根據尿微量清蛋白與尿肌酐比值(UACR)分為四組:(1)糖尿病非腎病組(DM組,UACR<30 mg/g)30例;(2)早期糖尿病腎病組(DN1組,UACR 30~300 mg/g)26例;(3)臨床糖尿病腎病組[DN2組,UACR>300 mg/g,血清肌酐(SCr)<133μmol/L]36例;(4)糖尿病腎病慢性腎功能衰竭組(DN3組,UACR>300 mg/g,SCr≥133μmol/L)32例。測定血清Hcy、SCr、BUN及糖化血紅蛋白(HbA1c)水平,併對檢測結果進行統計分析。結果四組檢測指標結果比較,Hcy、SCr、BUN水平均隨著疾病的嚴重程度呈升高趨勢。Hcy水平在DM組和DN1組、DN2組、DN3組間比較,差異均有統計學意義(P<0.05)。血清Hcy與UACR水平呈正相關(r=0.546,P<0.05),SCr水平與Hcy呈正相關(r=0.361,P<0.05),HbA1c水平與Hcy呈負相關(r=-0.203,P<0.05)。結論 Hcy高水平可能是2型糖尿病腎病進展的危險因素之一,與2型糖尿病腎病的髮生、髮展具有密切關繫,可作為2型糖尿病腎病早期診斷的臨床檢測指標。
목적:탐토동형반광안산(Hcy)수평재2형당뇨병신병발전중적변화급의의。방법수궤선취해원2013년1~12월주원치료적124례2형당뇨병환자,근거뇨미량청단백여뇨기항비치(UACR)분위사조:(1)당뇨병비신병조(DM조,UACR<30 mg/g)30례;(2)조기당뇨병신병조(DN1조,UACR 30~300 mg/g)26례;(3)림상당뇨병신병조[DN2조,UACR>300 mg/g,혈청기항(SCr)<133μmol/L]36례;(4)당뇨병신병만성신공능쇠갈조(DN3조,UACR>300 mg/g,SCr≥133μmol/L)32례。측정혈청Hcy、SCr、BUN급당화혈홍단백(HbA1c)수평,병대검측결과진행통계분석。결과사조검측지표결과비교,Hcy、SCr、BUN수평균수착질병적엄중정도정승고추세。Hcy수평재DM조화DN1조、DN2조、DN3조간비교,차이균유통계학의의(P<0.05)。혈청Hcy여UACR수평정정상관(r=0.546,P<0.05),SCr수평여Hcy정정상관(r=0.361,P<0.05),HbA1c수평여Hcy정부상관(r=-0.203,P<0.05)。결론 Hcy고수평가능시2형당뇨병신병진전적위험인소지일,여2형당뇨병신병적발생、발전구유밀절관계,가작위2형당뇨병신병조기진단적림상검측지표。
Objective To investigate the change and significance of homocysteine (Hcy) on the development of type 2 diabetic nephropathy(T2DN). Methods A total of 124 patients with type 2 diabetic mellitus,who were treated in the hospital from January to December of 2013,were selected randomly and divided into 4 groups according to urinary albumin to creatinine ratio (UACR):(1)the simple diabetes mellitus(DM) group(DM group,UACR<30 mg/g,n=30);(2)the early-stage diabetic nephropathy (DN) group(DN1 group,UACR 30-300 mg/g,n=26);(3)the clinical DN group[DN2 group,UACR>300 mg/d,serum creatinine (SCr)<133μmol/L,n=36];(4)DN uremia group (DN3 group,UACR>300 mg/d,SCr≥133μmol/L,n=32).The sera Hcy,SCr and blood urea nitrogen(BUN) in all the groups were determined and analyzed statistically. Results The levels of Hcy SCr and BUN in the 4 groups increased with the severity of disease. Compared with the DM group respectively ,the differences of Hcy in DN1 group,DN2 group and DN3 group all had statistical significance(P<0.05). Sera HCy was positively correlated with UACR level (r=0.546,P<0.05), SCr level was positively correlated with Hcy(r=0.361,P<0.05),and the haemoglobin A1c(HbA1c) level was negatively correlated with Hcy(r=-0.203,P<0.05). Conclusion High level of Hcy might be one of the risk factors for development of T2DN,and it is closely related with the occurrence and development of T2DN,so it can be considered as clinical indicators for early diagnosis of T2DN.