CAJ | 학술논문

目的：了解两种不同他汀类药物对不稳定型心绞痛患者的C-反应蛋白（ hs-CRP），白介素-18（ IL-18），基质蛋白酶-9（MMP-9）和血脂浓度的影响。方法选择2010年6月至2013年6月收治的60例不稳定型心绞痛患者作为研究对象。随机数字法分为两组，A组，30例，在常规治疗的基础上加用阿托伐他汀进行治疗；B组，30例，在常规治疗的基础上加用氟伐他汀进行治疗。测定并记录两组患者hs-CRP，IL-18，MMP-9，甘油三酯（ TG），总胆固醇（ TC），低密度脂蛋白-胆固醇（ LDL-C），高密度脂蛋白-胆固醇（ HDL-C），并进行对比分析。结果治疗后两组患者hs-CRP，IL-18，MMP-9均较治疗前显著降低，具有显著统计差异（ P <0.05），但组间治疗后水平无显著统计差异（ P >0.05）；治疗后两组患者的TG，TC，LDL-C，HDL-C均较治疗前明显改善，具有显著统计差异（ P <0.05），组间治疗后比较，A组TC水平较B组降低更明显，其余指标TG、LDL-C和HDL-C下降程度相比无显著统计差异（ P <0.05）；从不良反应发生率相比，两组在胃肠道症状和肝功能异常上相比具有显著统计差异（ P <0.05），而在急性冠状动脉病变上无显著统计差异（ P >0.05）。结论阿托伐他汀和氟伐他汀对降低不稳定型心绞痛患者的炎症反应和血脂均有一定疗效，虽然有不同程度的不良反应发生，但发生率都较低，在可控范围之内，因此两种他汀类药物是安全的，可靠的。
목적：료해량충불동타정류약물대불은정형심교통환자적C-반응단백（ hs-CRP），백개소-18（ IL-18），기질단백매-9（MMP-9）화혈지농도적영향。방법선택2010년6월지2013년6월수치적60례불은정형심교통환자작위연구대상。수궤수자법분위량조，A조，30례，재상규치료적기출상가용아탁벌타정진행치료；B조，30례，재상규치료적기출상가용불벌타정진행치료。측정병기록량조환자hs-CRP，IL-18，MMP-9，감유삼지（ TG），총담고순（ TC），저밀도지단백-담고순（ LDL-C），고밀도지단백-담고순（ HDL-C），병진행대비분석。결과치료후량조환자hs-CRP，IL-18，MMP-9균교치료전현저강저，구유현저통계차이（ P <0.05），단조간치료후수평무현저통계차이（ P >0.05）；치료후량조환자적TG，TC，LDL-C，HDL-C균교치료전명현개선，구유현저통계차이（ P <0.05），조간치료후비교，A조TC수평교B조강저경명현，기여지표TG、LDL-C화HDL-C하강정도상비무현저통계차이（ P <0.05）；종불량반응발생솔상비，량조재위장도증상화간공능이상상상비구유현저통계차이（ P <0.05），이재급성관상동맥병변상무현저통계차이（ P >0.05）。결론아탁벌타정화불벌타정대강저불은정형심교통환자적염증반응화혈지균유일정료효，수연유불동정도적불량반응발생，단발생솔도교저，재가공범위지내，인차량충타정류약물시안전적，가고적。
Objective To understand the influence of the C- reaction protein in patients with unstable angina pectoris of operation( hs-CRP),interleukin-18(IL-18),matrix metalloproteinase-9(MMP-9)and blood lipid concentration of two kinds of statins postoperative inflammatory factors. Methods 60 cases of unstable angina pectoris patients were treated in our hospital from 2010 June to 2013 June. All the 60 cases were included as the research object. All the cases were randomly divided into two groups,group A( including 30 cases)on the basis of con-ventional therapy plus treatment with atorvastatin,B group( including 30 cases)on the basis of conventional therapy plus treatment with fluvasta-tin. The hs-CRP,IL-18,MMP-9,TG,TC,LDL-C,HDL-C were measured,recorded,compared and analyzed. Results After treatment, hs-CRP,IL-18,and MMP-9 were therapy significantly less than before treatment,with significant statistical difference( P <0. 05). but there was no significant statistical difference between the two groups after the treatment( P >0. 05). The TG,TC,LDL-C,HDL-C of two groups of patients significantly improved compared with before treatment,with statistically significant differences( P <0. 05). The TC levels decreased more significantly. The remaining indicators including TG,LDL-C and HDL-C decreased significantly,with statistical differences( P <0. 05). The incidence of adverse reactions in the two groups were compared,there was significant statistical difference,including gastrointestinal symptoms and abnormal liver function( P <0. 05),while there was no significant statistical difference in acute coronary artery lesions( P >0. 05). Conclusion Inflammation and blood lipid effect of two different types of statins in patients with unstable angina pectoris on reducing postoperative are rela-tively strong,although the adverse reaction in different degree,the occurrence rate is still relatively low,in the controllable range. Therefore,the two kinds of statins is safe and reliable.