中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
33期
69-70
,共2页
蔺鹏珍%李国文%李璞%马丽萍%景葳%张文斐%赵超%秦华%梁丽华%郑刚%郭文婷
藺鵬珍%李國文%李璞%馬麗萍%景葳%張文斐%趙超%秦華%樑麗華%鄭剛%郭文婷
린붕진%리국문%리박%마려평%경위%장문비%조초%진화%량려화%정강%곽문정
聚乙二醇干扰素α-2a%双环醇%慢性乙型肝炎
聚乙二醇榦擾素α-2a%雙環醇%慢性乙型肝炎
취을이순간우소α-2a%쌍배순%만성을형간염
pegylated interferon α-2a%Bicyclol%Chronic hepatitis B
目的：探讨聚乙二醇干扰素α-2a联合双环醇治疗高转氨酶水平慢性乙型肝炎的疗效。方法：收治慢性乙型肝炎患者68例，根据不同用药方法，将其随机分为对照组及试验组各34例。对照组给予双环醇联合国产短效干扰素(凯因益生)治疗，试验组则给予聚乙二醇干扰素α-2a联合双环醇治疗。比较分析两组患者血清中ALT与AST含量、血清表面抗原含量以及乙肝病毒的DNA转阴率。结果：经有效治疗后，两组患者血清中ALT与AST含量、血清表面抗原含量以及乙肝病毒的DNA转阴率均呈现明显下降趋势，但试验组的下降趋势更为明显。结论：聚乙二醇干扰素α-2a联合双环醇对乙型肝炎病毒具有的抑制与消除作用更为明显，能更有效的降低慢性乙型肝炎的致死率，疗效显著，值得在临床上推广及应用。
目的：探討聚乙二醇榦擾素α-2a聯閤雙環醇治療高轉氨酶水平慢性乙型肝炎的療效。方法：收治慢性乙型肝炎患者68例，根據不同用藥方法，將其隨機分為對照組及試驗組各34例。對照組給予雙環醇聯閤國產短效榦擾素(凱因益生)治療，試驗組則給予聚乙二醇榦擾素α-2a聯閤雙環醇治療。比較分析兩組患者血清中ALT與AST含量、血清錶麵抗原含量以及乙肝病毒的DNA轉陰率。結果：經有效治療後，兩組患者血清中ALT與AST含量、血清錶麵抗原含量以及乙肝病毒的DNA轉陰率均呈現明顯下降趨勢，但試驗組的下降趨勢更為明顯。結論：聚乙二醇榦擾素α-2a聯閤雙環醇對乙型肝炎病毒具有的抑製與消除作用更為明顯，能更有效的降低慢性乙型肝炎的緻死率，療效顯著，值得在臨床上推廣及應用。
목적：탐토취을이순간우소α-2a연합쌍배순치료고전안매수평만성을형간염적료효。방법：수치만성을형간염환자68례，근거불동용약방법，장기수궤분위대조조급시험조각34례。대조조급여쌍배순연합국산단효간우소(개인익생)치료，시험조칙급여취을이순간우소α-2a연합쌍배순치료。비교분석량조환자혈청중ALT여AST함량、혈청표면항원함량이급을간병독적DNA전음솔。결과：경유효치료후，량조환자혈청중ALT여AST함량、혈청표면항원함량이급을간병독적DNA전음솔균정현명현하강추세，단시험조적하강추세경위명현。결론：취을이순간우소α-2a연합쌍배순대을형간염병독구유적억제여소제작용경위명현，능경유효적강저만성을형간염적치사솔，료효현저，치득재림상상추엄급응용。
Objective:To investigate the efficacy of pegylated interferon α-2a combined with bicyclol treating patients with chronic hepatitis B with high transaminase levels.Methods:68 patients with chronic hepatitis B were selected.According to the different treatment methods,they were randomly divided into the control group and the experimental group with 34 cases in each group.The control group were treated with bicyclol combined with domestic short acting interferon(Kaiyinyisheng).The experimental group were treated with PEG IFN α-2a united bicyclol.We compared the serum ALT and the content of AST,serum hepatitis B virus surface antigen content and DNA negative rate of the two groups.Results:After effective treatment,the serum ALT and AST content,serum hepatitis B virus surface antigen content and DNA negative rate of the two groups were significantly decreased,but the trend of the experimental group was more obvious.Conclusion:Suppression and elimination effect is more obvious.It can effectively reduce the death rate of chronic hepatitis B.The effect is obvious.It is worthy of promotion and application in clinical.
