CAJ | 학술논문

目的：观察盐酸川芎嗪联合辅酶Q10对不稳定型心绞痛患者炎症反应和免疫功能的影响。方法将不稳定型心绞痛患者215例随机分为联合用药组110例和对照组105例。联合用药组在常规治疗基础上给予盐酸川芎嗪80 mg／d和辅酶Q1010 mg／d静点，对照组仅给予常规治疗。治疗2周后观察2组临床疗效，检测治疗前后炎性因子白细胞介素－2（ IL－2）、肿瘤坏死因子－α（ TNF－α）、超敏C反应蛋白（ hs－CRP）水平，免疫球蛋白IgA、IgG、IgM及免疫细胞亚群CD3＋、CD4＋、CD4＋／CD8＋水平。结果联合用药组的有效率为89．09％，对照组为78．10％，联合用药组有效率高于对照组（P＜0．05）；联合用药组心电图改善率为88．18％，高于对照组的75．24％（P＜0．05）；2组治疗后IL－2、TNF－α、hs－CRP水平较治疗前均明显降低（P均＜0．05），且联合用药组治疗后各指标水平均低于同时点对照组（P均＜0．05）；治疗后2组IgA、IgG、IgM、CD3＋、CD4＋、CD4＋／CD8＋水平均明显降低；与对照组比较，除CD4＋／CD8＋外，各指标水平联合用药组降低更为明显（ P均＜0．05）。结论盐酸川芎嗪联合辅酶Q10用于治疗不稳定型心绞痛效果良好，具有抑制全身炎症反应、改善免疫功能的作用。
목적：관찰염산천궁진연합보매Q10대불은정형심교통환자염증반응화면역공능적영향。방법장불은정형심교통환자215례수궤분위연합용약조110례화대조조105례。연합용약조재상규치료기출상급여염산천궁진80 mg／d화보매Q1010 mg／d정점，대조조부급여상규치료。치료2주후관찰2조림상료효，검측치료전후염성인자백세포개소－2（ IL－2）、종류배사인자－α（ TNF－α）、초민C반응단백（ hs－CRP）수평，면역구단백IgA、IgG、IgM급면역세포아군CD3＋、CD4＋、CD4＋／CD8＋수평。결과연합용약조적유효솔위89．09％，대조조위78．10％，연합용약조유효솔고우대조조（P＜0．05）；연합용약조심전도개선솔위88．18％，고우대조조적75．24％（P＜0．05）；2조치료후IL－2、TNF－α、hs－CRP수평교치료전균명현강저（P균＜0．05），차연합용약조치료후각지표수평균저우동시점대조조（P균＜0．05）；치료후2조IgA、IgG、IgM、CD3＋、CD4＋、CD4＋／CD8＋수평균명현강저；여대조조비교，제CD4＋／CD8＋외，각지표수평연합용약조강저경위명현（ P균＜0．05）。결론염산천궁진연합보매Q10용우치료불은정형심교통효과량호，구유억제전신염증반응、개선면역공능적작용。
Objective It is to observe the effect of Ligustrazine Hydrochloride combined with Coenzyme Q10 on inflammato-ry reaction and immunologic function in patients with unstable angina pectoris.Methods 215 subjects with unstable angina pectoris were randomly divided into 2 groups:combination group (n=110) and control group (n=105).Combination group was treated with ligustrazine hydrochloride(80 mg/d) combined with coenzyme Q10 (10 mg/d) by intravenous infusion and conventional therapy, and the control group was treated with conventional treatment only.After two weeks'treatment, the clini-cal curative effect in both groups were observed and the levels of inflammatory factors, such as IL-2 , TNF-α, high sensitiv-ity C-reactive protein( hs-CRP) and levels of IgA, IgG, IgM, lymphocyte subsets CD3 +, CD4 +, CD4 +/CD8 +in periph-eral blood were all determined.Results The effective rate was 89.09% in combination group, which was higher than that of 78.10%in control group(all P<0.05); the improving rate of ECG in combination group was 88.18%, which was higher than that of 75.24%in control group(P<0.05).After treatment, the levels of IL-2, TNF-α, hs-CRP were all increased compared with pretreatment, and all indexes showed more obvious changes in combination group than that in control group( P<0.05).The levels of IgA, IgG, IgM, CD3 +, CD4 +, in both groups decreased significantly, and the levels of these inde-xes changed more significantly in combination group (P<0.05), whereas there was no significance about CD4 +/CD8 +be-tween the two groups(P>0.05).Conclusion Ligustrazine hydrochloride combined with coenzyme Q10 has a good curative effect on unstable angina pectoris, which can relieve inflammatory reaction and improve immunologic functions.