CAJ | 학술논문

目的：探讨阿托伐他汀对原发性高血压患者肿瘤坏死因子－α（TNF －α）、白介素－6（IL －6）、超敏 C 反应蛋白（hs －CRP）和血管内皮舒张功能的影响。方法选取原发性高血压患者50例，随机分为2组，常规组25例予常规降压药物治疗，实验组25例予常规降压药物联合阿托伐他汀治疗。分别于治疗前和治疗后检测2组患者的血压、低密度脂蛋白（LDL）、总胆固醇（TC）、三酰甘油（TG）、TNF －α、 IL －6、hs－ CRP 和血管内皮舒张功能情况。结果治疗8周后常规组和实验组收缩压均显著降低（P 均＜0．05），且实验组收缩压降低程度明显大于常规组（P ＜0．05）；实验组 LDL、TC 和 TG 均明显下降（P 均＜0．05），血管内皮舒张功能亦获得明显改善（P ＜0．05）；2组 TNF －α、IL －6和 hs －CRP 水平较前均显著降低（P均＜0．05），且实验组各指标下降幅度均较常规组更大（P 均＜0．05）。结论对于原发性高血压患者，在常规口服降压药物的同时联合使用阿托伐他汀，可明显降低血压，并明显降低血脂、抑制炎症因子及改善患者血管内皮功能。
목적：탐토아탁벌타정대원발성고혈압환자종류배사인자－α（TNF －α）、백개소－6（IL －6）、초민 C 반응단백（hs －CRP）화혈관내피서장공능적영향。방법선취원발성고혈압환자50례，수궤분위2조，상규조25례여상규강압약물치료，실험조25례여상규강압약물연합아탁벌타정치료。분별우치료전화치료후검측2조환자적혈압、저밀도지단백（LDL）、총담고순（TC）、삼선감유（TG）、TNF －α、 IL －6、hs－ CRP 화혈관내피서장공능정황。결과치료8주후상규조화실험조수축압균현저강저（P 균＜0．05），차실험조수축압강저정도명현대우상규조（P ＜0．05）；실험조 LDL、TC 화 TG 균명현하강（P 균＜0．05），혈관내피서장공능역획득명현개선（P ＜0．05）；2조 TNF －α、IL －6화 hs －CRP 수평교전균현저강저（P균＜0．05），차실험조각지표하강폭도균교상규조경대（P 균＜0．05）。결론대우원발성고혈압환자，재상규구복강압약물적동시연합사용아탁벌타정，가명현강저혈압，병명현강저혈지、억제염증인자급개선환자혈관내피공능。
Objective To investigate the effect of atorvastatin on TNF -α、IL -6、hs -CRP and endothelial function in pa-tients with hypertension.Methods A total of 50 patients who had essential hypertension were recruited.They were randomly divided into conventional group (who received conventional anti-hypertensive drugs, n =25) and experiment group (who re-ceived conventional anti-hypertensive drugs combined with atorvastatin treatment, n =25).The changes of blood pressure, blood lipids and vascular endothelial function were recorded before and after the treatment.Results After a -8 -week regular treatment, both the conventional group and experiment group had a more lower blood pressure when compared with the previous level (P <0.05).The blood pressure decreased (31.25 ±4.14) mmHg in conventional group and (37.83 ±6.19) mmHg in experiment group, there was significant difference between the 2 groups (P <0.05).Both of the 2 groups had a significant de-crease in TNF -α, IL -6 and hs -CRP(P <0.05), but the experiment group had a more ideal recovery in these index(P <0.05).Only the experiment group had an improvement in LDL,TC ,TG amd vascular endothelial function (P <0.05).Con-clusions:For essential hypertension patients, conventional anti-hypertensive drugs combined with atorvastatin treatment not on-ly could improve the the blood lipids, inflammatory cytokines level and vascular endothelial function, but also obtain a more preferable blood pressure control.