CAJ | 학술논문

早产儿脑白质损伤是低出生和极低出生体重儿脑损伤的主要形式,但其病因及发病机制尚未完全明确.目前认为Toll样受体在脑白质损伤的发病机制中起重要作用.Toll样受体是天然免疫受体家族,Toll样受体信号通路被激活可分泌大量TNF-α、IL-1β、活性氧、活性氮、NO等炎症因子,促使免疫应答反应发生.神经免疫应答对脑白质产生损伤,即脑内小胶质活化和星形胶质增殖.Toll样受体为脑白质损伤等疾病预防治疗提供新的研究方向.该文对Toll样受体在早产儿脑白质损伤性疾病中的研究进展作一综述.
조산인뇌백질손상시저출생화겁저출생체중인뇌손상적주요형식,단기병인급발병궤제상미완전명학.목전인위Toll양수체재뇌백질손상적발병궤제중기중요작용.Toll양수체시천연면역수체가족,Toll양수체신호통로피격활가분비대량TNF-α、IL-1β、활성양、활성담、NO등염증인자,촉사면역응답반응발생.신경면역응답대뇌백질산생손상,즉뇌내소효질활화화성형효질증식.Toll양수체위뇌백질손상등질병예방치료제공신적연구방향.해문대Toll양수체재조산인뇌백질손상성질병중적연구진전작일종술.
White matter damage in premature infant is the main form of brain damage in low birth and very low birth weight children,but its etiology and pathogenesis is not fully clear.Present studies show that Tolllike receptors(TLR) play an important role in the white matter damage mechanism.TLRs are regulators of innate immune responses.The studies have found that TLRs signaling pathway is activated to secrete large amounts of TNF-α,IL-1β,reactive oxygen species (ROS) and reactive nitrogen (RNS),NO,and other inflammatory factors,inducing the immune response.Nerve immune response damages brain white matter,namely the activation of microglia and proliferation of astrocytes in brain.TLRs provide a new research direction for prevention and treatment.Therefore,the research and progress of toll-like receptors in premature brain white matter injury disease are