CAJ | 학술논문

目的：观察强化、序贯阿托伐他汀钙治疗急性脑梗死的临床疗效。方法选择2012年6月～2013年6月来自本院神经内科就诊的100例脑梗死患者入组，患者均在发病后24小时内入院并符合急性缺血性脑卒中的临床诊断，随机分为治疗组与对照组，治疗组50例，对照组50例，治疗组加用阿托伐他汀钙40 mg，口服，每天一次，强化治疗14天后，改20 mg，口服，序贯治疗21天。对照组不使用阿托伐他汀钙。两组患者的活血化瘀、抗血小板聚集、脑细胞代谢等神经科治疗药物、康复方案相同，分别在治疗前和治疗后5周进行NIHSS（美国国立卫生院脑卒中量表）神经功能缺损评分、日常生活活动能力（activities of dailyliving ADL）量表评分以及改良Rankinj量表（Modified Rankin Scale，MRS）评分，进行效疗评定。结果治疗后，治疗组的NIHSS评分、ADL评分、改良Rankinj量表评分均有明显降低，较对照组有显著差异（P＜0.05）。治疗组临床治疗效果优于对照组（P<0.05）。结论强化、序贯阿托伐他汀钙治疗脑梗死有显著临床效果。
목적：관찰강화、서관아탁벌타정개치료급성뇌경사적림상료효。방법선택2012년6월～2013년6월래자본원신경내과취진적100례뇌경사환자입조，환자균재발병후24소시내입원병부합급성결혈성뇌졸중적림상진단，수궤분위치료조여대조조，치료조50례，대조조50례，치료조가용아탁벌타정개40 mg，구복，매천일차，강화치료14천후，개20 mg，구복，서관치료21천。대조조불사용아탁벌타정개。량조환자적활혈화어、항혈소판취집、뇌세포대사등신경과치료약물、강복방안상동，분별재치료전화치료후5주진행NIHSS（미국국립위생원뇌졸중량표）신경공능결손평분、일상생활활동능력（activities of dailyliving ADL）량표평분이급개량Rankinj량표（Modified Rankin Scale，MRS）평분，진행효료평정。결과치료후，치료조적NIHSS평분、ADL평분、개량Rankinj량표평분균유명현강저，교대조조유현저차이（P＜0.05）。치료조림상치료효과우우대조조（P<0.05）。결론강화、서관아탁벌타정개치료뇌경사유현저림상효과。
ObjectiveTo observe the clinical effects of atorvastatin calcium in strengthened and sequential used for treated of acute cerebral infarction.Methods From June 2012 to June 2013,100 cases of patient diagnosed with cerebral infarction were enrolled at department of internal neurology in our hospital. They were randomly divided into treatment group (n=50) and control group (n=50). The treatment group was administrated atorvastatin calcium 40mg, oral, once a day. And after 14 days, it was changed to 20mg, oral, sequential therapy for 21 days. The control group was not given atorvastatin calcium. The blood circulation, anti-platelet aggregation, brain cell metabolism and other neurological treatment drug, and rehabilitation protocol were the same in two groups. The nerve function defect (NIHSS score), ability of daily life (ADL scale) and modiifed Rankin scale were evaluated before treatment and after 5 weeks. Also, the clinical effects were compared.Results After the treatment, the NIHSS score, ADL score and the modified Rankin scale score in treatment group were lower than those in the control group, the differences were statistically signiifcant (P<0.05). The effect of clinical treatment in treatment group was better than the control group (P<0.05)Conclusion Atorvastatin calcium in strengthened and sequential using has signiifcant clinical effect on treating cerebral infarction.