化工技术与开发
化工技術與開髮
화공기술여개발
TECHNOLOGY & DVELOPMENT OF CHEMICAL INDUSTRY
2014年
11期
25-26,49
,共3页
N-叔丁氧羰基-D-天冬氨酸-β-苄酯%D-脯氨酸甲酯盐酸盐%环(D-天冬氨-D-脯)%合成
N-叔丁氧羰基-D-天鼕氨痠-β-芐酯%D-脯氨痠甲酯鹽痠鹽%環(D-天鼕氨-D-脯)%閤成
N-숙정양탄기-D-천동안산-β-변지%D-포안산갑지염산염%배(D-천동안-D-포)%합성
N-tertbutyloxycarbonyl-D-aspartic acid-β-benzylester%D-proline methyl ester hydrochloride%cyclo(D-Asp-D-Pro)%synthesis
以D-天冬氨酸和D-脯氨酸为原料，先合成N-叔丁氧羰基-D-天冬氨酸-β-苄酯和D-脯氨酸甲酯盐酸盐，然后经DCC缩合得直链二肽，再经Pd/C催化氢解，HCl/Et2O脱Boc保护，最后弱碱性条件下成环得环（D-天冬氨-D-脯）二肽，结构经ESI-MS、IR、1HNMR、13CNMR等表征。
以D-天鼕氨痠和D-脯氨痠為原料，先閤成N-叔丁氧羰基-D-天鼕氨痠-β-芐酯和D-脯氨痠甲酯鹽痠鹽，然後經DCC縮閤得直鏈二肽，再經Pd/C催化氫解，HCl/Et2O脫Boc保護，最後弱堿性條件下成環得環（D-天鼕氨-D-脯）二肽，結構經ESI-MS、IR、1HNMR、13CNMR等錶徵。
이D-천동안산화D-포안산위원료，선합성N-숙정양탄기-D-천동안산-β-변지화D-포안산갑지염산염，연후경DCC축합득직련이태，재경Pd/C최화경해，HCl/Et2O탈Boc보호，최후약감성조건하성배득배（D-천동안-D-포）이태，결구경ESI-MS、IR、1HNMR、13CNMR등표정。
The synthesis of cyclo(D-Asp-D-Pro)was reported in this paper. First, N-tertbutyloxycarbonyl-D-aspartic acid-β-benzylester and D-proline methyl ester hydrochloride were synthesized from D-aspartic acid and D-proline. Then, after DCC condensation, Pd/C catalytic hydrogenation, deprotection of tertbutyloxycarbonyl group with aether solution of hydrogen chloride and cyclization with NaHCO3 solution, cyclodipeptide cyclo(D-Asp-D-Pro) was obtained. The structure was identified by ESI-MS, IR, 1HNMR and 13CNMR.
