蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2014年
11期
1557-1558,1561
,共3页
王卫国%马芳%李玉云%张夏%郭进京%王伟伟
王衛國%馬芳%李玉雲%張夏%郭進京%王偉偉
왕위국%마방%리옥운%장하%곽진경%왕위위
白血病%血管性血友病因子%乳酸脱氢酶%超敏C反应蛋白
白血病%血管性血友病因子%乳痠脫氫酶%超敏C反應蛋白
백혈병%혈관성혈우병인자%유산탈경매%초민C반응단백
leukemia%von willebrand factor%lactate dehydrogenase%high sensitive C-reactive protein
目的：初步探讨急性白血病( AL)患者血管性血友病因子抗原( vWF：Ag)检测的临床意义。方法：39例AL患者( AL组),外周血白细胞计数>50×109/L 15例,<50×109/L 24例,21名健康体检者为正常对照组(对照组)。使用CA-7000血凝仪检测vWF：Ag、D-二聚体及纤维蛋白(原)降解产物( FDPs)；使用7600型生化分析仪检测乳酸脱氢酶( LDH)和超敏C反应蛋白( hs-CRP)；全血细胞计数采用迈瑞6800型血细胞分析仪。结果：AL组的vWF：Ag、D-二聚体、FDPs、LDH和hs-CRP水平均明显高于对照组(P<0.01)；白细胞>50×109/L的患者vWF：Ag和LDH均高于白细胞<50×109/L的患者(P<0.05和P<0.01),vWF：Ag与D-二聚体、FDPs、LDH和hs-CRP水平均呈正相关关系(P<0.05)。结论：AL患者存在以vWF：Ag升高为表现的内皮细胞损伤,这种表现与肿瘤负荷、急性期反应和纤溶亢进有关。
目的：初步探討急性白血病( AL)患者血管性血友病因子抗原( vWF：Ag)檢測的臨床意義。方法：39例AL患者( AL組),外週血白細胞計數>50×109/L 15例,<50×109/L 24例,21名健康體檢者為正常對照組(對照組)。使用CA-7000血凝儀檢測vWF：Ag、D-二聚體及纖維蛋白(原)降解產物( FDPs)；使用7600型生化分析儀檢測乳痠脫氫酶( LDH)和超敏C反應蛋白( hs-CRP)；全血細胞計數採用邁瑞6800型血細胞分析儀。結果：AL組的vWF：Ag、D-二聚體、FDPs、LDH和hs-CRP水平均明顯高于對照組(P<0.01)；白細胞>50×109/L的患者vWF：Ag和LDH均高于白細胞<50×109/L的患者(P<0.05和P<0.01),vWF：Ag與D-二聚體、FDPs、LDH和hs-CRP水平均呈正相關關繫(P<0.05)。結論：AL患者存在以vWF：Ag升高為錶現的內皮細胞損傷,這種錶現與腫瘤負荷、急性期反應和纖溶亢進有關。
목적：초보탐토급성백혈병( AL)환자혈관성혈우병인자항원( vWF：Ag)검측적림상의의。방법：39례AL환자( AL조),외주혈백세포계수>50×109/L 15례,<50×109/L 24례,21명건강체검자위정상대조조(대조조)。사용CA-7000혈응의검측vWF：Ag、D-이취체급섬유단백(원)강해산물( FDPs)；사용7600형생화분석의검측유산탈경매( LDH)화초민C반응단백( hs-CRP)；전혈세포계수채용매서6800형혈세포분석의。결과：AL조적vWF：Ag、D-이취체、FDPs、LDH화hs-CRP수평균명현고우대조조(P<0.01)；백세포>50×109/L적환자vWF：Ag화LDH균고우백세포<50×109/L적환자(P<0.05화P<0.01),vWF：Ag여D-이취체、FDPs、LDH화hs-CRP수평균정정상관관계(P<0.05)。결론：AL환자존재이vWF：Ag승고위표현적내피세포손상,저충표현여종류부하、급성기반응화섬용항진유관。
Objective:To explore the clinical meaning of von willebrand factor antigen(vWF:Ag) detection in patients with acute leukemia. Methods:The levels of vWF:Ag,D-dimer and fibrin/fibrinogen degradation products(FDPs) were detected by CA-7000 coagulation analyzer,the levels of lactate dehydrogenase( LDH) and high sensitive C-reactive protein( hs-CRP) were detected by 7600 automated biochemistry analyzer,the complete blood counts were tested by Mindray 6 800 hematology analyzer in 39 patients with acute leukemia(including 15 cases with WBC>50 í109/L and 24 cases with <50 í109/L) and 21 normal controls. Results:Compared with the control group,the levels of vWF:Ag,D-dimer,FDPs,LDH and hs-CRP were higher in acute leukemia patients(P<0. 01),the levels of vWF:Ag and LDH were higher in acute leukemia patients with WBC>50í109/L than those with WBC<50í109/L( P<0. 05 and P<0. 01),vWF:Ag had the positive correlations with D-dimer,FDPs,LDH and hs-CRP. Conclusions:The endothelial cell injury was happened in patients with acute leukemia,which presented as the increase of vWF:Ag,the manifestation was correlated with tumor load,acute phase response and hyperfibrinolysis.
