蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2014年
11期
1521-1523,1527
,共4页
结核性胸膜炎%糖类抗原125%腺苷脱氨酶%胸水
結覈性胸膜炎%糖類抗原125%腺苷脫氨酶%胸水
결핵성흉막염%당류항원125%선감탈안매%흉수
tuberculous pleurisy%cancer antigen 125%adenosine deaminase%hydrothorax
目的：探讨胸水糖类抗原125(CA125)、腺苷脱氨酶(ADA)联合检测在结核性胸膜炎诊断中的临床意义。方法：应用电化学发光法测定54例结核性胸膜炎及40例恶性胸腔积液患者胸水CA125、ADA,同时检测胸水中癌胚抗原、CA199、神经特异性烯醇化酶、细胞角质素片段抗原。结果：结核性胸膜炎患者胸水CA125的水平[(702.67依367.30)u/ml]高于正常值,胸水ADA水平[(81.74依18.82)u/L]增高,胸水CA125的灵敏度(100.0%)高于胸水ADA(88.9%)。其余4项肿瘤指标阳性率低。胸水CA125联合ADA检测有较高的灵敏度(88.9%)及特异度(90.75%)。结论：胸水CA125测定对结核性胸膜炎的诊断具有临床价值,CA125联合胸水ADA检测可提高结核性胸膜炎的诊断阳性率,联合其他肿瘤指标测定有助于排除恶性胸腔积液。
目的：探討胸水糖類抗原125(CA125)、腺苷脫氨酶(ADA)聯閤檢測在結覈性胸膜炎診斷中的臨床意義。方法：應用電化學髮光法測定54例結覈性胸膜炎及40例噁性胸腔積液患者胸水CA125、ADA,同時檢測胸水中癌胚抗原、CA199、神經特異性烯醇化酶、細胞角質素片段抗原。結果：結覈性胸膜炎患者胸水CA125的水平[(702.67依367.30)u/ml]高于正常值,胸水ADA水平[(81.74依18.82)u/L]增高,胸水CA125的靈敏度(100.0%)高于胸水ADA(88.9%)。其餘4項腫瘤指標暘性率低。胸水CA125聯閤ADA檢測有較高的靈敏度(88.9%)及特異度(90.75%)。結論：胸水CA125測定對結覈性胸膜炎的診斷具有臨床價值,CA125聯閤胸水ADA檢測可提高結覈性胸膜炎的診斷暘性率,聯閤其他腫瘤指標測定有助于排除噁性胸腔積液。
목적：탐토흉수당류항원125(CA125)、선감탈안매(ADA)연합검측재결핵성흉막염진단중적림상의의。방법：응용전화학발광법측정54례결핵성흉막염급40례악성흉강적액환자흉수CA125、ADA,동시검측흉수중암배항원、CA199、신경특이성희순화매、세포각질소편단항원。결과：결핵성흉막염환자흉수CA125적수평[(702.67의367.30)u/ml]고우정상치,흉수ADA수평[(81.74의18.82)u/L]증고,흉수CA125적령민도(100.0%)고우흉수ADA(88.9%)。기여4항종류지표양성솔저。흉수CA125연합ADA검측유교고적령민도(88.9%)급특이도(90.75%)。결론：흉수CA125측정대결핵성흉막염적진단구유림상개치,CA125연합흉수ADA검측가제고결핵성흉막염적진단양성솔,연합기타종류지표측정유조우배제악성흉강적액。
Objective:To explore the clinical significance of the joint detection of carbohydrate antigen 125(CA125) and adenosine deaminase( ADA) in hydrothorax in the diagnosis of tuberculous pleurisy. Methods:The levels of CA125 and ADA in hydrothorax of 54 patients with tuberculous pleurisy and 40 patients with malignant pleural effusion were measured using electrochemiluminescence assay. The four tumor markers(including carcino embryonic antigen,CA199,neuron-specific enolase,cylokerain fragments21 -1 were also detected. Results:The concentrations of CA125 and ADA in hydrothorax of tuberculous pleurisy were(702. 67 ± 367. 30) u/ml and (81. 74±18. 82)u/L,respectively,whose were higher than the normal level. The sensitivity of CA125(100. 0%) was higher than that of ADA(88. 9%) in hydrothorax. The positive rates of four tumor markers were low. The sensitivity and specificity of the joint detection of CA125 and ADA could be increased to 88. 9% and 90. 75%,respectively. Conclusions:The measurement of CA125 is beneficial in the diagnosis of tuberculous pleurisy. The combined detection of CA125 and ADA can improve the diagnostic positive rate of tuberculous pleurisy,combined other tumor indexes detection can help to exclude malignant pleural effusion.
