中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2014年
12期
1354-1357
,共4页
干燥综合征%白介素 7%免疫球蛋白类%C 反应蛋白
榦燥綜閤徵%白介素 7%免疫毬蛋白類%C 反應蛋白
간조종합정%백개소 7%면역구단백류%C 반응단백
Sj?gren's syndrome%Interleukin - 7%Immunoglobulins%C - reactive protein
目的：探讨白介素7（IL -7）在原发性干燥综合征（pSS）患者唇腺组织中的表达及其与唇腺组织中淋巴细胞浸润和红细胞沉降率（ESR）、C 反应蛋白（CRP）、免疫球蛋白的相关性。方法选择2005年3月—2012年10月滨州市人民医院风湿免疫科门诊及住院的 pSS 患者30例为 pSS 组，另选择同时期颌面部创伤和唇腺囊肿患者5例为对照组。采用免疫组织化学法检测唇腺组织中 IL -7的表达情况，采用 HE 染色法检测唇腺组织中淋巴细胞浸润情况。分析 IL -7与唇腺组织中淋巴细胞浸润及 ESR、CRP、免疫球蛋白的相关性。结果 IL -7阳性产物定位于胞质，呈棕黄色，主要表达于导管、腺泡上皮细胞及淋巴细胞浸润灶。pSS 组29例呈阳性表达，阳性表达率为97%，对照组1例呈阳性表达，两组 IL -7阳性表达率比较，差异有统计学意义（P =0,013）。IL -7阳性细胞数与淋巴细胞浸润灶数呈正相关（r =0,807，P <0,01），与 ESR 呈正相关（r =0,546，P <0,01），与 CRP、IgG、IgM、IgA 无相关性（P>0,05）。结论 IL -7在 pSS 患者唇腺组织中呈高表达，表达情况与淋巴细胞浸润及 ESR 相关，高表达的 IL -7可能在 pSS 唇腺组织的破坏及发病过程中起重要作用。
目的：探討白介素7（IL -7）在原髮性榦燥綜閤徵（pSS）患者脣腺組織中的錶達及其與脣腺組織中淋巴細胞浸潤和紅細胞沉降率（ESR）、C 反應蛋白（CRP）、免疫毬蛋白的相關性。方法選擇2005年3月—2012年10月濱州市人民醫院風濕免疫科門診及住院的 pSS 患者30例為 pSS 組，另選擇同時期頜麵部創傷和脣腺囊腫患者5例為對照組。採用免疫組織化學法檢測脣腺組織中 IL -7的錶達情況，採用 HE 染色法檢測脣腺組織中淋巴細胞浸潤情況。分析 IL -7與脣腺組織中淋巴細胞浸潤及 ESR、CRP、免疫毬蛋白的相關性。結果 IL -7暘性產物定位于胞質，呈棕黃色，主要錶達于導管、腺泡上皮細胞及淋巴細胞浸潤竈。pSS 組29例呈暘性錶達，暘性錶達率為97%，對照組1例呈暘性錶達，兩組 IL -7暘性錶達率比較，差異有統計學意義（P =0,013）。IL -7暘性細胞數與淋巴細胞浸潤竈數呈正相關（r =0,807，P <0,01），與 ESR 呈正相關（r =0,546，P <0,01），與 CRP、IgG、IgM、IgA 無相關性（P>0,05）。結論 IL -7在 pSS 患者脣腺組織中呈高錶達，錶達情況與淋巴細胞浸潤及 ESR 相關，高錶達的 IL -7可能在 pSS 脣腺組織的破壞及髮病過程中起重要作用。
목적：탐토백개소7（IL -7）재원발성간조종합정（pSS）환자진선조직중적표체급기여진선조직중림파세포침윤화홍세포침강솔（ESR）、C 반응단백（CRP）、면역구단백적상관성。방법선택2005년3월—2012년10월빈주시인민의원풍습면역과문진급주원적 pSS 환자30례위 pSS 조，령선택동시기합면부창상화진선낭종환자5례위대조조。채용면역조직화학법검측진선조직중 IL -7적표체정황，채용 HE 염색법검측진선조직중림파세포침윤정황。분석 IL -7여진선조직중림파세포침윤급 ESR、CRP、면역구단백적상관성。결과 IL -7양성산물정위우포질，정종황색，주요표체우도관、선포상피세포급림파세포침윤조。pSS 조29례정양성표체，양성표체솔위97%，대조조1례정양성표체，량조 IL -7양성표체솔비교，차이유통계학의의（P =0,013）。IL -7양성세포수여림파세포침윤조수정정상관（r =0,807，P <0,01），여 ESR 정정상관（r =0,546，P <0,01），여 CRP、IgG、IgM、IgA 무상관성（P>0,05）。결론 IL -7재 pSS 환자진선조직중정고표체，표체정황여림파세포침윤급 ESR 상관，고표체적 IL -7가능재 pSS 진선조직적파배급발병과정중기중요작용。
Objective To study the expression of interleukin - 7(IL - 7)in the labial gland of patients with primary Sj?gren's syndrome(pSS)and its relationship with the infiltration of lymphocytes in the gland,serum erythrocyte sedimentation rate(ESR),C - reactive protein(CRP)and immunoglobulin, Methods 30 pSS inpatients and outpatients from the Department of Rheumatism of Binzhou People's Hospital from March 2005 to October 2012 were selected as pSS group,while 5 patients with maxillofacial trauma and labial gland cyst of the same period were selected as control group, Immunohistochemical method was used to detect the expression of IL - 7 in labial gland,and HE staining was used to detect the lymphocyte infiltration in labial gland, The relationship between IL - 7 and infiltration of lymphocytes in the gland,serum ESR,CRP and immunoglobulin was analyzed, Results IL - 7 was expressed in the acini,ducts and lymphocytes infiltration area in pSS, 29 cases of pSS group had positive expression,and the positive expression rate of IL - 7 was 97% , One case of the control group had positive expression, and the positive expression of IL - 7 between the two groups showed statistically significant difference(P = 0, 013), The positive cells of IL - 7 positively were correlated with the lymphocyte infiltration focus and ESR( r = 0, 807,0, 546,P < 0, 01),but were not correlated with CRP,IgG,IgM and IgA(P > 0, 05), Conclusion The elevation of IL - 7 expression in labial gland in patients with pSS is related to the infiltration of lymphocytes and ESR,which plays an important role in the process of glandular destruction and in the pathogenesis of pSS.
