CAJ | 학술논문

目的：探讨黑加仑籽粉对肾性高血压大鼠血压和血浆内皮素-1(endothelin-1, ET-1)、血清一氧化氮( nitric oxide, NO)、超氧化物歧化酶( superoxide dismutase, SOD)、丙二醛( malonic di-aldehyde, MDA)的影响。方法将实验SD雄鼠随机分为假手术组、模型组、卡托普利组、黑加仑籽粉组,灌胃给药8周,假手术组、模型组给予等容量蒸馏水,于给药前及给药后定期对SD大鼠血压进行测量,并对给药8周后SD大鼠血浆中的ET-1含量,血清中的SOD活力、NO及MDA含量进行测定。结果给药8周后,与假手术组相比,模型组的血压、血浆中ET-1含量、血清中MDA的含量均明显升高( P<0．01),且血清中NO含量及SOD活力明显降低( P<0．01或P<0．05)；与模型组相比,卡托普利组、黑加仑籽粉组的血压明显下降(P<0．01),血浆中ET-1含量及血清中MDA的含量均明显降低(P<0．01),血清中 NO的含量明显升高(P<0．01),SOD活力无显著性差异(P>0．05)。结论黑加仑籽粉对肾性高血压大鼠具有降压作用,推测其作用途径可能与通过抗氧化作用来保护血管内皮细胞,改善血管内皮功能有关。
목적：탐토흑가륜자분대신성고혈압대서혈압화혈장내피소-1(endothelin-1, ET-1)、혈청일양화담( nitric oxide, NO)、초양화물기화매( superoxide dismutase, SOD)、병이철( malonic di-aldehyde, MDA)적영향。방법장실험SD웅서수궤분위가수술조、모형조、잡탁보리조、흑가륜자분조,관위급약8주,가수술조、모형조급여등용량증류수,우급약전급급약후정기대SD대서혈압진행측량,병대급약8주후SD대서혈장중적ET-1함량,혈청중적SOD활력、NO급MDA함량진행측정。결과급약8주후,여가수술조상비,모형조적혈압、혈장중ET-1함량、혈청중MDA적함량균명현승고( P<0．01),차혈청중NO함량급SOD활력명현강저( P<0．01혹P<0．05)；여모형조상비,잡탁보리조、흑가륜자분조적혈압명현하강(P<0．01),혈장중ET-1함량급혈청중MDA적함량균명현강저(P<0．01),혈청중 NO적함량명현승고(P<0．01),SOD활력무현저성차이(P>0．05)。결론흑가륜자분대신성고혈압대서구유강압작용,추측기작용도경가능여통과항양화작용래보호혈관내피세포,개선혈관내피공능유관。
Objective To observe the effects of blackcurrant seed powder on blood pressure in re-novascular hypertensive rats and endothelin-1 (ET-1) in plasma, nitric oxide(NO), superoxide dismutase ( SOD) , malonic dialdehyde ( MDA) in serum. Methods The experimental SD male rats were randomly divided into sham group, model group , captopril group , blackcurrant seed powder groups. ,After eight weeks of gavage administration, sham group , model group were given the same volume of distilled water. Measurements of blood pressure in SD rats before and after treatment, and 8 weeks after treatment of SD rat determine ET-1 levels in plasma , NO and SOD activity , MDA in serum. Results After 8 weeks, com-pared with the sham group, model group blood pressure, ET-1 levels in plasma, MDA levels in serum were significantly increased (P<0. 01), and NO levels and SOD activity in serum was significantly lower (P<0. 01 or P<0. 05 ); compared with the model group, captopril , blackcurrant seed powder group blood pressure decreased significantly (P<0. 01);and captopril group and blackcurrant seed powder groups can significantly reduce ET-1 levels in plasma ( P<0. 01 ) , MDA levels in serum ( P<0. 01 ) , increased NO in serum(P<0. 01) , captopril group and blackcurrant seed powder group the activity of SOD in serum has no significant difference (P>0. 05). Conclusions Blackcurrant seed powder has antihypertensive effect to renovascular hypertensive rats, the pathway may be used to protect endothelial cells through antioxida-tive, improve endothelial function.