化工学报
化工學報
화공학보
JOURNAL OF CHEMICAL INDUSY AND ENGINEERING (CHINA)
2014年
12期
5090-5096
,共7页
李瑜%刘媛媛%李帅%梁刚%张亚男%胡庆夕
李瑜%劉媛媛%李帥%樑剛%張亞男%鬍慶夕
리유%류원원%리수%량강%장아남%호경석
海藻酸钠%聚合物加工%中空纤维%浸取%凝胶%凝胶率%溶胀度
海藻痠鈉%聚閤物加工%中空纖維%浸取%凝膠%凝膠率%溶脹度
해조산납%취합물가공%중공섬유%침취%응효%응효솔%용창도
sodium alginate%polymer processing%hollow fiber%leaching%gels%gel fraction%swelling degree
以海藻酸钠为原料、氯化钙为交联剂,反应直写制备海藻酸钙水凝胶中空纤维及组织工程支架。纤维的凝胶率和溶胀度直接影响支架的成形质量与所装载细胞的存活率。浸取分离所直写中空纤维的未交联部分,分析材料浓度对凝胶率的影响;以滴注凝固浴制备的海藻酸钙微球为对照组,分析直写工艺的溶胀度表现。结果表明,以4%海藻酸钠与3%氯化钙材料交联直写的中空纤维凝胶率和纤维形貌较好地满足了直写工艺的要求;随着海藻酸钠浓度的增加,中空纤维的溶胀度先减小后小幅升高并趋于稳定;随着氯化钙浓度的增加,凝胶纤维的溶胀度逐渐减小;反应直写工艺由于较小的两相接触表面,其溶胀度比凝固浴制备凝胶微球高2~5倍,更高的含水率有利于保障所装载细胞的活性和传质。
以海藻痠鈉為原料、氯化鈣為交聯劑,反應直寫製備海藻痠鈣水凝膠中空纖維及組織工程支架。纖維的凝膠率和溶脹度直接影響支架的成形質量與所裝載細胞的存活率。浸取分離所直寫中空纖維的未交聯部分,分析材料濃度對凝膠率的影響;以滴註凝固浴製備的海藻痠鈣微毬為對照組,分析直寫工藝的溶脹度錶現。結果錶明,以4%海藻痠鈉與3%氯化鈣材料交聯直寫的中空纖維凝膠率和纖維形貌較好地滿足瞭直寫工藝的要求;隨著海藻痠鈉濃度的增加,中空纖維的溶脹度先減小後小幅升高併趨于穩定;隨著氯化鈣濃度的增加,凝膠纖維的溶脹度逐漸減小;反應直寫工藝由于較小的兩相接觸錶麵,其溶脹度比凝固浴製備凝膠微毬高2~5倍,更高的含水率有利于保障所裝載細胞的活性和傳質。
이해조산납위원료、록화개위교련제,반응직사제비해조산개수응효중공섬유급조직공정지가。섬유적응효솔화용창도직접영향지가적성형질량여소장재세포적존활솔。침취분리소직사중공섬유적미교련부분,분석재료농도대응효솔적영향;이적주응고욕제비적해조산개미구위대조조,분석직사공예적용창도표현。결과표명,이4%해조산납여3%록화개재료교련직사적중공섬유응효솔화섬유형모교호지만족료직사공예적요구;수착해조산납농도적증가,중공섬유적용창도선감소후소폭승고병추우은정;수착록화개농도적증가,응효섬유적용창도축점감소;반응직사공예유우교소적량상접촉표면,기용창도비응고욕제비응효미구고2~5배,경고적함수솔유리우보장소장재세포적활성화전질。
With sodium alginate as raw material and calcium chloride as crosslinker, a hollow hydrogel fiber was fabricated by direct writing combined with crosslinking, and was used to construct tissue engineering scaffold. Fiber gel fraction and swelling degree directly affect the forming quality of scaffold and laden cell survival. The influence of materials concentration on gel fraction was analyzed by leaching the ungelled part from the fiber. As a control group, alginate beads were prepared with coagulating bath. The requirements of direct writing process, such as gel rate, gel fraction and fiber morphology were satisfied, when the concentration of sodium alginate and calcium chloride were 4% and 3% respectively. With increasing sodium alginate’s concentration, equilibrium swelling degree of hollow fiber first decreased and then slightly increased and stabilized finally. With increasing calcium chloride’s concentration, swelling degree gradually decreased. Due to smaller diffusion interface, swelling degree of hollow fiber was two to five times higher than the gelled beads, and higher moisture was in favor of the viability and mass transfer for cell laden.