浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
21期
1782-1783,1790
,共3页
陆玉良%程震锋%韦凡平%邱升强
陸玉良%程震鋒%韋凡平%邱升彊
륙옥량%정진봉%위범평%구승강
妊娠期高血压疾病%同型半胱氨酸%叶酸%维生素B12
妊娠期高血壓疾病%同型半胱氨痠%葉痠%維生素B12
임신기고혈압질병%동형반광안산%협산%유생소B12
Hypertensive disorder complicating pregnancy%Homocysteine%Folic Acid%Vitamin B12
目的：探讨高龄妊娠期高血压疾病患者血浆总同型半胱氨酸（tHcy）、血清叶酸和Vit B12水平3者的关系及其临床意义。方法选择67例高龄妊娠期高血压疾病患者（A组）、96例同期非高龄妊娠期高血压疾病患者（B组）、73例同期高龄妊娠妇女（C组）和152例同期非高龄妊娠妇女（D组），用荧光偏振免疫分析法测定血浆tHcy水平，离子捕捉免疫分析法测定血清叶酸水平，微粒子酶联免疫分析法测定血清Vit B12水平，进行分析和比较。结果 A组血浆tHcy水平、血清叶酸和Vit B12水平分别为（18.05±6.11）μmol/L、（8.34±3.54）nmol/L 和（304.23±75.38）pmol/L，B 组分别为（11.18±3.54）μmol/L、（12.36±4.53）nmol/L 和（364.23±89.35）pmol/L，C组分别为（8.21±3.76）μmol/L、（15.54±5.23）nmol/L和（404.53±92.35）pmol/L，D组分别为（7.81±3.23）μmol/L、（16.34±5.67）nmol/L和（421.73±113.55）pmol/L。A组tHcy水平高于其他3组（均P＜0.01），叶酸和Vit B12水平则低于其他3组（均P＜0.01），B组tHcy水平高于C组和D组（均P＜0.01），叶酸和Vit B12水平则低于C组和D组（均P＜0.01）。相关性分析显示，A、B两组血浆tHcy水平与血清叶酸、Vit B12水平均呈负相关性（r=-0.6372、-0.5747，均P＜0.01），而在A组中表现更加明显，其血浆tHcy水平与血清叶酸、Vit B12水平呈高度负相关（r=-0.7653、-0.6843，均P＜0.01）。结论妊娠期高血压疾病患者血浆tHcy浓度显著上升，血清叶酸、Vit B12浓度显著下降，随着怀孕年龄的增加这种负相关更加明显。
目的：探討高齡妊娠期高血壓疾病患者血漿總同型半胱氨痠（tHcy）、血清葉痠和Vit B12水平3者的關繫及其臨床意義。方法選擇67例高齡妊娠期高血壓疾病患者（A組）、96例同期非高齡妊娠期高血壓疾病患者（B組）、73例同期高齡妊娠婦女（C組）和152例同期非高齡妊娠婦女（D組），用熒光偏振免疫分析法測定血漿tHcy水平，離子捕捉免疫分析法測定血清葉痠水平，微粒子酶聯免疫分析法測定血清Vit B12水平，進行分析和比較。結果 A組血漿tHcy水平、血清葉痠和Vit B12水平分彆為（18.05±6.11）μmol/L、（8.34±3.54）nmol/L 和（304.23±75.38）pmol/L，B 組分彆為（11.18±3.54）μmol/L、（12.36±4.53）nmol/L 和（364.23±89.35）pmol/L，C組分彆為（8.21±3.76）μmol/L、（15.54±5.23）nmol/L和（404.53±92.35）pmol/L，D組分彆為（7.81±3.23）μmol/L、（16.34±5.67）nmol/L和（421.73±113.55）pmol/L。A組tHcy水平高于其他3組（均P＜0.01），葉痠和Vit B12水平則低于其他3組（均P＜0.01），B組tHcy水平高于C組和D組（均P＜0.01），葉痠和Vit B12水平則低于C組和D組（均P＜0.01）。相關性分析顯示，A、B兩組血漿tHcy水平與血清葉痠、Vit B12水平均呈負相關性（r=-0.6372、-0.5747，均P＜0.01），而在A組中錶現更加明顯，其血漿tHcy水平與血清葉痠、Vit B12水平呈高度負相關（r=-0.7653、-0.6843，均P＜0.01）。結論妊娠期高血壓疾病患者血漿tHcy濃度顯著上升，血清葉痠、Vit B12濃度顯著下降，隨著懷孕年齡的增加這種負相關更加明顯。
목적：탐토고령임신기고혈압질병환자혈장총동형반광안산（tHcy）、혈청협산화Vit B12수평3자적관계급기림상의의。방법선택67례고령임신기고혈압질병환자（A조）、96례동기비고령임신기고혈압질병환자（B조）、73례동기고령임신부녀（C조）화152례동기비고령임신부녀（D조），용형광편진면역분석법측정혈장tHcy수평，리자포착면역분석법측정혈청협산수평，미입자매련면역분석법측정혈청Vit B12수평，진행분석화비교。결과 A조혈장tHcy수평、혈청협산화Vit B12수평분별위（18.05±6.11）μmol/L、（8.34±3.54）nmol/L 화（304.23±75.38）pmol/L，B 조분별위（11.18±3.54）μmol/L、（12.36±4.53）nmol/L 화（364.23±89.35）pmol/L，C조분별위（8.21±3.76）μmol/L、（15.54±5.23）nmol/L화（404.53±92.35）pmol/L，D조분별위（7.81±3.23）μmol/L、（16.34±5.67）nmol/L화（421.73±113.55）pmol/L。A조tHcy수평고우기타3조（균P＜0.01），협산화Vit B12수평칙저우기타3조（균P＜0.01），B조tHcy수평고우C조화D조（균P＜0.01），협산화Vit B12수평칙저우C조화D조（균P＜0.01）。상관성분석현시，A、B량조혈장tHcy수평여혈청협산、Vit B12수평균정부상관성（r=-0.6372、-0.5747，균P＜0.01），이재A조중표현경가명현，기혈장tHcy수평여혈청협산、Vit B12수평정고도부상관（r=-0.7653、-0.6843，균P＜0.01）。결론임신기고혈압질병환자혈장tHcy농도현저상승，혈청협산、Vit B12농도현저하강，수착부잉년령적증가저충부상관경가명현。
Objective To determine plasma total homocysteine (tHcy) and its relationship with folic acid and vitamin B12 in elder pregnant women with gestational hypertension. Methods Plasma tHcy, serum folic acid and vit B12 level were determined by fluorescence polarization immunoassay (FPIA), ion capture immunoassay (ICIA) and microparticle enzyme immunoassay (MEIA) in 67 elder patients with gestational hypertension (group A), 96 normal age patients with gestational hypertension(group B), 73 normal elder pregnant women (group C) and 152 normal age pregnant women(group D), respectively. Results The mean plasma tHcy levels were(18.05±6.11), (11.18±3.54), (8.21±3.76) and (7.81±3.23)μmol/L in groups A, B, C and D, respective-ly. The serum folic acid levels were (8.34±3.54), (12.36±4.53), (15.54±5.23) and (16.34±5.67)nmol/L in groups A. B, C and D, respectively. The mean serum VitB12 levels were (304.23±75.38), (364.23±89.35), (404.53±92.35) and (421.73±113.55)pmol/L in groups A, B, C and D, respectively. The level of plasma tHcy in group A was the highest in the four groups (P<0.01), but the levels of serum folic acid and vitB12 in group A were the lowest in four groups(P<0.01). The levels of plasma tHcy in group B were higher, but serum folic acid and vitB12 levels were lower than those in group C and group D (both P<0.01). Correlation analysis showed that plasma tHcy was negatively correlated with serum folic acid and vitB12 in groups A and B (r=- 0.6372、- 0.5747, P<0.01);and it was more significantly in group A(r=- 0.7653、- 0.6843, P<0.01). Conclusion The levels of plasma tHcy in elder pa-tients with gestational hypertension are significantly increased, while the levels of serum folic acid and vitB12 are significantly de-creased. The negative correlation is more significantly showed with the growing age of pregnancy.
