中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2014年
7期
766-770
,共5页
陈戈%段洪%卞鸿燕%贺云%尹劲%吴波%杨海青%周兆文
陳戈%段洪%卞鴻燕%賀雲%尹勁%吳波%楊海青%週兆文
진과%단홍%변홍연%하운%윤경%오파%양해청%주조문
骨质疏松%脊柱退行性疾病%统计分析
骨質疏鬆%脊柱退行性疾病%統計分析
골질소송%척주퇴행성질병%통계분석
Osteoporosis%Spinal degenerative disease%Statistical analysis
目的：研究低转换型骨质疏松与脊柱退行性疾病之间的相互关系，并探讨骨质疏松对老年人脊柱退变的危害。方法使用双能X线骨密度测量仪检测，临床观察及影像学资料，大样本随机抽样，spss13．0统计学软件对数据进行分析，研究一年来505例50岁以上的患者，分析统计低转换型骨质疏松症的脊柱病变。结果各年龄组不同腰椎椎体骨密度之间比较采用单因素方差分析，计数资料采用Spearman等级相关分析，骨质疏松与腰椎失稳等疾病之间的相关分析采用非条件logistic回归分析。发现胸腰椎骨折的偏回归系数为1．026，Wald检验结果P＝0．021＜0．05，有统计学意义，OR值为2．789；脊柱退行性变的偏回归系数为0．225，Wald检验结果P＝0．035＜0．05，有统计学意义，OR值为2．253；腰椎失稳的偏回归系数为0．828，Wald检验结果P＝0．004＜0．05，有统计学意义，OR值为2．289；腰椎滑脱的偏回归系数为0．782，Wald检验结果P＝0．024＜0．05，有统计学意义，OR值为2．185；颈椎病的偏回归系数为0．691，Wald检验结果P＝0．045＜0．05，有统计学意义，OR值为1．211；椎管狭窄的偏回归系数为0．972，Wald检验结果P＝0．031＜0．05，有统计学意义，OR值为2．570；脊柱畸形的偏回归系数为0．972，Wald检验结果P＝0．025＜0．05，有统计学意义，OR值为1．002；年龄的偏回归系数为0．048，Wald检验结果P＝0．000＜0．05，有统计学意义，OR值为1．049；性别的偏回归系数为－1．035，Wald检验结果P＝0．000＜0．05，有统计学意义，OR值为0．355。骨质疏松，脊柱退行性病（脊柱退行性变、脊柱不稳、胸腰椎骨折、椎管狭窄、脊柱畸形、颈椎病、脊柱滑脱）与年龄增加相关。结论年龄增加，低转换型骨质疏松增加；骨量丢失，骨质疏松能加速脊柱退变。骨质疏松加速脊柱退行性变、脊柱不稳、胸腰椎骨折、椎管狭窄、脊柱畸形、颈椎病、脊柱滑脱等脊柱退行性疾病的发病。
目的：研究低轉換型骨質疏鬆與脊柱退行性疾病之間的相互關繫，併探討骨質疏鬆對老年人脊柱退變的危害。方法使用雙能X線骨密度測量儀檢測，臨床觀察及影像學資料，大樣本隨機抽樣，spss13．0統計學軟件對數據進行分析，研究一年來505例50歲以上的患者，分析統計低轉換型骨質疏鬆癥的脊柱病變。結果各年齡組不同腰椎椎體骨密度之間比較採用單因素方差分析，計數資料採用Spearman等級相關分析，骨質疏鬆與腰椎失穩等疾病之間的相關分析採用非條件logistic迴歸分析。髮現胸腰椎骨摺的偏迴歸繫數為1．026，Wald檢驗結果P＝0．021＜0．05，有統計學意義，OR值為2．789；脊柱退行性變的偏迴歸繫數為0．225，Wald檢驗結果P＝0．035＜0．05，有統計學意義，OR值為2．253；腰椎失穩的偏迴歸繫數為0．828，Wald檢驗結果P＝0．004＜0．05，有統計學意義，OR值為2．289；腰椎滑脫的偏迴歸繫數為0．782，Wald檢驗結果P＝0．024＜0．05，有統計學意義，OR值為2．185；頸椎病的偏迴歸繫數為0．691，Wald檢驗結果P＝0．045＜0．05，有統計學意義，OR值為1．211；椎管狹窄的偏迴歸繫數為0．972，Wald檢驗結果P＝0．031＜0．05，有統計學意義，OR值為2．570；脊柱畸形的偏迴歸繫數為0．972，Wald檢驗結果P＝0．025＜0．05，有統計學意義，OR值為1．002；年齡的偏迴歸繫數為0．048，Wald檢驗結果P＝0．000＜0．05，有統計學意義，OR值為1．049；性彆的偏迴歸繫數為－1．035，Wald檢驗結果P＝0．000＜0．05，有統計學意義，OR值為0．355。骨質疏鬆，脊柱退行性病（脊柱退行性變、脊柱不穩、胸腰椎骨摺、椎管狹窄、脊柱畸形、頸椎病、脊柱滑脫）與年齡增加相關。結論年齡增加，低轉換型骨質疏鬆增加；骨量丟失，骨質疏鬆能加速脊柱退變。骨質疏鬆加速脊柱退行性變、脊柱不穩、胸腰椎骨摺、椎管狹窄、脊柱畸形、頸椎病、脊柱滑脫等脊柱退行性疾病的髮病。
목적：연구저전환형골질소송여척주퇴행성질병지간적상호관계，병탐토골질소송대노년인척주퇴변적위해。방법사용쌍능X선골밀도측량의검측，림상관찰급영상학자료，대양본수궤추양，spss13．0통계학연건대수거진행분석，연구일년래505례50세이상적환자，분석통계저전환형골질소송증적척주병변。결과각년령조불동요추추체골밀도지간비교채용단인소방차분석，계수자료채용Spearman등급상관분석，골질소송여요추실은등질병지간적상관분석채용비조건logistic회귀분석。발현흉요추골절적편회귀계수위1．026，Wald검험결과P＝0．021＜0．05，유통계학의의，OR치위2．789；척주퇴행성변적편회귀계수위0．225，Wald검험결과P＝0．035＜0．05，유통계학의의，OR치위2．253；요추실은적편회귀계수위0．828，Wald검험결과P＝0．004＜0．05，유통계학의의，OR치위2．289；요추활탈적편회귀계수위0．782，Wald검험결과P＝0．024＜0．05，유통계학의의，OR치위2．185；경추병적편회귀계수위0．691，Wald검험결과P＝0．045＜0．05，유통계학의의，OR치위1．211；추관협착적편회귀계수위0．972，Wald검험결과P＝0．031＜0．05，유통계학의의，OR치위2．570；척주기형적편회귀계수위0．972，Wald검험결과P＝0．025＜0．05，유통계학의의，OR치위1．002；년령적편회귀계수위0．048，Wald검험결과P＝0．000＜0．05，유통계학의의，OR치위1．049；성별적편회귀계수위－1．035，Wald검험결과P＝0．000＜0．05，유통계학의의，OR치위0．355。골질소송，척주퇴행성병（척주퇴행성변、척주불은、흉요추골절、추관협착、척주기형、경추병、척주활탈）여년령증가상관。결론년령증가，저전환형골질소송증가；골량주실，골질소송능가속척주퇴변。골질소송가속척주퇴행성변、척주불은、흉요추골절、추관협착、척주기형、경추병、척주활탈등척주퇴행성질병적발병。
Objective To investigate the relationship between low remodelling osteoporosis and the spinal degenerative diseases, and to explore the damage of osteoporosis on the spine degeneration in the elderly patients.Methods The bone mineral density ( BMD) was detected using dual-energy X-ray absorptiometry.The clinical observation and the collection of the imaging data were performed.The large-sample random sampling was also performed.A SPSS 13.0 statistical software was used to analyze all the data of 505 patients over 50 years old in a year.The data of the spinal diseases with low remodelling osteoporosis were collected. Results The comparison of BMD of different lumbar vertebrae in each group was performed using single factor analysis of variance.The enumeration data were analyzed using Spearman rank correlation analysis.The correlation between osteoporosis and diseases such as the lumbar instability was analyzed using non-conditional logistic regression analysis.The results revealed that the partial regression coefficient of the thoraco-lumbar fracture was 1.026 (P=0.021, OR 2.789).The partial regression coefficient of the spinal degeneration was 0.225 (P=0.035, OR 2.253).The partial regression coefficient of the lumbar instability was 0.828 (P=0.004, OR 2.289).The partial regression coefficient of the spondylolisthesis was 0.782 (P=0.024, OR 2.185).The partial regression coefficient of the cervical spondylosis was 0.691 (P=0.045, OR 1.211).The partial regression coefficient of the spinal stenosis was 0.972 (P=0.031, OR 2.57).The partial regression coefficient of the spinal deformity was 0.972 (P=0.025, OR 1.002).The partial regression coefficient of age was 0.048 (P=0.000, OR 1.049).The partial regression coefficient of gender was -1.035 (P=0.000, OR 0.355).Osteoporosis and the spinal degenerative diseases, including the spinal degeneration, the spinal instability, the thoraco-lumbar fractures, the spinal stenosis, the spinal deformity, the cervical spondylosis, and the spondylolisthesis, were correlated with the increase of age.Conclusion Along with the increase of age, the incindence of low remodeling osteoporosis increases.Bone loss and osteoporosis can both accelerate the spinal degeneration.Osteoporosis can also accelerate the spinal degenerative diseases, such as the spinal degeneration, the spinal instability, the thoraco-lumbar fractures, the spinal stenosis, the spinal deformity, the cervical spondylosis, and the spondylolisthesis.
