中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2014年
7期
747-749
,共3页
张金赫%尹吉林%邓伟民%王成%禹晖%章明%梁瑛%安文峰%姜丽莎
張金赫%尹吉林%鄧偉民%王成%禹暉%章明%樑瑛%安文峰%薑麗莎
장금혁%윤길림%산위민%왕성%우휘%장명%량영%안문봉%강려사
甲状腺机能减退%骨密度%体脂含量%甲状腺癌
甲狀腺機能減退%骨密度%體脂含量%甲狀腺癌
갑상선궤능감퇴%골밀도%체지함량%갑상선암
Hypothyroidism%Bone mineral density%Adipose tissue distribution%Thyroid carcinoma
目的:观察短期甲状腺机能减退对患者骨密度及脂肪分布的影响,探讨二者之间的相关性。方法选择甲状腺癌患者22例,均行甲状腺全切术或近全切术,术后4~8周或停用左甲状腺素后3~6周均行131 I去除治疗(去除治疗后48小时即开始使用左旋甲状腺素),对该组病例术前、131 I治疗前,131 I治疗后3~6个月,分别行全身骨密度测定及脂肪分布测定。结果22例甲癌患者,术前游离三碘甲状腺原氨酸(FT3)平均为(4.55±0.91)pmol/L,术后4~6周平均为(1.21±0.41)pmol /L,131 I治疗后3~6个月平均为(5.70±1.17) pmol /L;三次骨密度测定,无明显变化;三次体脂含量分别为21.75±8.01 kg,23.05±7.96 kg,21.53±7.73 kg,甲减状态时,体脂含量明显增加(第二次减去第一次,P<0.01);甲减恢复后,体脂含量亦随之基本恢复(第三次减去第一次,P=0.36)。结论短期甲减对患者骨密度无明显影响,但可使患者体脂含量明显增高,且该改变随着甲状腺机能减退的纠正而逐渐恢复。
目的:觀察短期甲狀腺機能減退對患者骨密度及脂肪分佈的影響,探討二者之間的相關性。方法選擇甲狀腺癌患者22例,均行甲狀腺全切術或近全切術,術後4~8週或停用左甲狀腺素後3~6週均行131 I去除治療(去除治療後48小時即開始使用左鏇甲狀腺素),對該組病例術前、131 I治療前,131 I治療後3~6箇月,分彆行全身骨密度測定及脂肪分佈測定。結果22例甲癌患者,術前遊離三碘甲狀腺原氨痠(FT3)平均為(4.55±0.91)pmol/L,術後4~6週平均為(1.21±0.41)pmol /L,131 I治療後3~6箇月平均為(5.70±1.17) pmol /L;三次骨密度測定,無明顯變化;三次體脂含量分彆為21.75±8.01 kg,23.05±7.96 kg,21.53±7.73 kg,甲減狀態時,體脂含量明顯增加(第二次減去第一次,P<0.01);甲減恢複後,體脂含量亦隨之基本恢複(第三次減去第一次,P=0.36)。結論短期甲減對患者骨密度無明顯影響,但可使患者體脂含量明顯增高,且該改變隨著甲狀腺機能減退的糾正而逐漸恢複。
목적:관찰단기갑상선궤능감퇴대환자골밀도급지방분포적영향,탐토이자지간적상관성。방법선택갑상선암환자22례,균행갑상선전절술혹근전절술,술후4~8주혹정용좌갑상선소후3~6주균행131 I거제치료(거제치료후48소시즉개시사용좌선갑상선소),대해조병례술전、131 I치료전,131 I치료후3~6개월,분별행전신골밀도측정급지방분포측정。결과22례갑암환자,술전유리삼전갑상선원안산(FT3)평균위(4.55±0.91)pmol/L,술후4~6주평균위(1.21±0.41)pmol /L,131 I치료후3~6개월평균위(5.70±1.17) pmol /L;삼차골밀도측정,무명현변화;삼차체지함량분별위21.75±8.01 kg,23.05±7.96 kg,21.53±7.73 kg,갑감상태시,체지함량명현증가(제이차감거제일차,P<0.01);갑감회복후,체지함량역수지기본회복(제삼차감거제일차,P=0.36)。결론단기갑감대환자골밀도무명현영향,단가사환자체지함량명현증고,차해개변수착갑상선궤능감퇴적규정이축점회복。
Objective To observe the effect of short-term hypothyroidism after the surgery for hyroid carcinoma on bone mineral density ( BMD) and fat distribution, and to investigate the correlation between them.Methods Twenty-two patients with thyroid cancer were selected.All these patients underwent total thyroidectomy or subtotal resection.The 131I removal treatment began at the 4th to the 8th week after the operation or at the 3rd to the 6th week after the discontinuation of levothyroxine.The application of levothyroxine started at the 48th hour after the 131I removal treatment.BMD and fat distribution of all the patients were detected before the operation, before the 131I treatment, and 3-6 months after the treatment of 131I, respectively.Results Among all these 22 patients with thyroid cancer, the average levels of free triiodothyronine ( FT3 ) before the operation, 4 -6 weeks after operation, and 3-6 months after treatment of 131I were 4.55 ±0.91 pmol/L, 1.21 ±0.41 pmol/L, and 5.70 ±1.17 pmol/L, respectively.BMD determination showed no significant changes.The body fat contents were 21.75 ±8.01 kg, 23.05 ±7.96 kg, 21.53 ±7.73 kg, respectively.Body fat content increased significantly during hypothyroidism ( the second level minus the first one, P<0.01).After recovering from hypothyroidism, body fat content also recovered (the third level minus the first one, P=0.36). Conclusion The short-term hypothyroidism has no effect on BMD of the patients, but can make the body fat content increase significantly.And the changes gradually recover after the correction of hypothyroidism.