CAJ | 학술논문

目的：探讨不同临床处理对体外授精-胚胎移植（ in vitro fertilization and embryo transfer， IVF-ET）中伴溢乳症的不孕症患者妊娠结局的影响。方法选择在邢台不孕不育专科医院生殖中心接受IVF-ET的不孕症患者358例，其中伴溢乳症296例，无溢乳症及基础血清催乳素（ prolactin，PRL）正常的62例。按有无溢乳症、高PRL血症及其处理方法分为5组，A组为溢乳症不伴有高PRL血症，应用甲磺酸溴隐亭治疗；B组为溢乳症伴有高PRL血症，应用甲磺酸溴隐亭治疗；C组为溢乳症不伴有高PRL血症，应用中药治疗；D组为溢乳症不伴有高PRL血症，未给予药物治疗；E组为无溢乳症及基础血清PRL正常。比较5组不孕症患者外源性促性腺激素（ gonadotropin，Gn ）启动日 PRL 水平、注射绒毛膜促性腺激素（ chorionic gonadotrophin，HCG）日PRL水平、获卵数、可用胚胎数、临床妊娠率。结果5组不孕症患者比较，A组临床妊娠率最低（P<0.05）；在Gn启动日和注射HCG日，A组PRL水平低于其他4组（P<0.05）。结论不孕症患者无高PRL血症的溢乳症状无需进行治疗，为改善症状，中药治疗可作为很好的尝试。
목적：탐토불동림상처리대체외수정-배태이식（ in vitro fertilization and embryo transfer， IVF-ET）중반일유증적불잉증환자임신결국적영향。방법선택재형태불잉불육전과의원생식중심접수IVF-ET적불잉증환자358례，기중반일유증296례，무일유증급기출혈청최유소（ prolactin，PRL）정상적62례。안유무일유증、고PRL혈증급기처리방법분위5조，A조위일유증불반유고PRL혈증，응용갑광산추은정치료；B조위일유증반유고PRL혈증，응용갑광산추은정치료；C조위일유증불반유고PRL혈증，응용중약치료；D조위일유증불반유고PRL혈증，미급여약물치료；E조위무일유증급기출혈청PRL정상。비교5조불잉증환자외원성촉성선격소（ gonadotropin，Gn ）계동일 PRL 수평、주사융모막촉성선격소（ chorionic gonadotrophin，HCG）일PRL수평、획란수、가용배태수、림상임신솔。결과5조불잉증환자비교，A조림상임신솔최저（P<0.05）；재Gn계동일화주사HCG일，A조PRL수평저우기타4조（P<0.05）。결론불잉증환자무고PRL혈증적일유증상무수진행치료，위개선증상，중약치료가작위흔호적상시。
Objective To investigate the impact of different clinical treatments on pregnant results in infertility patients underWent vitro fertilization embryo transfer( IVF-ET)accompanying With galactorrhea syndrome. Methods 358 cases of infertility patients Who underWent IVF-ET in The Repraduction Center of Xingtai Infertility Specialized Hospital Were selected,of Whom 296 cases Were With galactorrhea syndrome,62 cases Were of normal serum prolactin( PRL)Without galactorrhea syndrome. The patients Were divided into 5 groups,Group A:patients of normal PRL With galactorrhea syndrome under treatment of bromocriptine mesilate,Group B:patients With hyperprolactinemia and galactorrhea syndrome under treatment of bromocriptine mesilate,Group C:patients of normal PRL With galactorrhea syndrome under treatment of traditional chinese medicine,Group D:patients of normal PRL With galactorrhea syndrome involving no treatment,Group E:patients of normal PRL Without galactorrhea syndrome. PRL level at the start date of eXogenous gonadotropin( Gn),PRL level at the day of injecting chorionic gonadotrophin( HCG),the number of oocyte,the number of available embryos and clinical pregnancy rate of 5 groups Were compared. Results The clinical pregnancy rate of group A Was the loWest(P<0. 05),at the start date of Gn and the day of injecting HCG,the PRL level of group A Was loWer than that of the other 4 groups(P<0. 05). Conclusion There is no need of treatment for infertility patients With galactorrhea syndrome but of normal PRL, traditional chinese medicine can be used to improve symptoms.