中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2014年
8期
964-967,977
,共5页
绝经后骨质疏松%血管生成%三七总皂苷
絕經後骨質疏鬆%血管生成%三七總皂苷
절경후골질소송%혈관생성%삼칠총조감
Postmenopausal osteoporosis%Angiogenesis%Panax notoginseng saponins
骨质疏松症是危害人类生命和健康的重大疾病,而具有“四高一低”特点的绝经后骨质疏松症的发病率呈逐年攀升趋势,该病的防治研究日益引起医学界的关注。瘀血是绝经后骨质疏松症的重要机理之一,而微血管的改变则是瘀血证的病理基础。血管生成在生理性骨生长和骨重建,以及在病理性骨疾病中均具有重要作用,并能够一定程度上反映骨局部再生过程,因此血管生成与骨质疏松症存在密切关联。活血化瘀中药能够直接或间接的刺激血管生成,三七总皂苷具有独特的药理活性,能够通过促进血管生成治疗缺血性疾病,相关研究报道日渐积累。但以三七总皂苷为研究对象,以血管生成为治疗靶点,挖掘并阐释药物通过促进血管新生治疗绝经后骨质疏松症,尚未见国内外相关报道。本文旨在以血管生成为靶点挖掘三七总皂苷改善绝经后骨质疏松症的新途径,以期为同道进一步深入研究及其临床应用参阅。
骨質疏鬆癥是危害人類生命和健康的重大疾病,而具有“四高一低”特點的絕經後骨質疏鬆癥的髮病率呈逐年攀升趨勢,該病的防治研究日益引起醫學界的關註。瘀血是絕經後骨質疏鬆癥的重要機理之一,而微血管的改變則是瘀血證的病理基礎。血管生成在生理性骨生長和骨重建,以及在病理性骨疾病中均具有重要作用,併能夠一定程度上反映骨跼部再生過程,因此血管生成與骨質疏鬆癥存在密切關聯。活血化瘀中藥能夠直接或間接的刺激血管生成,三七總皂苷具有獨特的藥理活性,能夠通過促進血管生成治療缺血性疾病,相關研究報道日漸積纍。但以三七總皂苷為研究對象,以血管生成為治療靶點,挖掘併闡釋藥物通過促進血管新生治療絕經後骨質疏鬆癥,尚未見國內外相關報道。本文旨在以血管生成為靶點挖掘三七總皂苷改善絕經後骨質疏鬆癥的新途徑,以期為同道進一步深入研究及其臨床應用參閱。
골질소송증시위해인류생명화건강적중대질병,이구유“사고일저”특점적절경후골질소송증적발병솔정축년반승추세,해병적방치연구일익인기의학계적관주。어혈시절경후골질소송증적중요궤리지일,이미혈관적개변칙시어혈증적병리기출。혈관생성재생이성골생장화골중건,이급재병이성골질병중균구유중요작용,병능구일정정도상반영골국부재생과정,인차혈관생성여골질소송증존재밀절관련。활혈화어중약능구직접혹간접적자격혈관생성,삼칠총조감구유독특적약리활성,능구통과촉진혈관생성치료결혈성질병,상관연구보도일점적루。단이삼칠총조감위연구대상,이혈관생성위치료파점,알굴병천석약물통과촉진혈관신생치료절경후골질소송증,상미견국내외상관보도。본문지재이혈관생성위파점알굴삼칠총조감개선절경후골질소송증적신도경,이기위동도진일보심입연구급기림상응용삼열。
Osteoporosis is a major disease, which hazards human life and health.However, with characteristics of“four high and one low”, the incidence of postmenopausal osteoporosis is rising year by year, and the prevention research has attracted the concern of the medical field increasingly. Blood stasis is one of the important mechanisms in the pathogenesis of postmenopausal osteoporosis, and the changes in microvascular blood are the pathological basis of stasis.Angiogenesis plays an important role in physiological bone growth and bone remodeling, as well as in pathological bone diseases, and it can reflect the local bone regeneration process to some extent.Thus, angiogenesis is closely related to osteoporosis.Some blood-circulation-activating traditional Chinese drugs can stimulate angiogenesis directly or indirectly.Panax notoginseng saponins ( PNS ) has a unique pharmacological activity, which promotes angiogenesis in the treatment of ischemic diseases.The related research reports accumulate increasingly.But there is no related report nationally and internationally using PNS as a research object and angiogenesis as a therapeutic target to investigate the treatment of postmenopausal osteoporosis by promoting angiogenesis.This article aims to provide a new way to explore PNS in relieving postmenopausal osteoporosis by promoting angiogenesis, which could be refered for further in-depth mechanistic and clinical studies.