CAJ | 학술논문

目的：研究老年男性抑郁情绪对原发性骨质疏松症的影响及其机制。方法选取于我院老年科住院的老年男性原发性骨质疏松患者68例（骨质疏松组）和非骨质疏松患者66例（对照组），老年抑郁量表（ GDS）评估抑郁值，双能X线测定骨密度，放射免疫法测定血浆皮质醇（Cor）、促肾上腺皮质激素（ACTH）、睾酮（T）的水平，酶联免疫吸附法测定白介素－6（IL－6）、去甲肾上腺素（NA）、5－羟色胺（5－HT）水平，比较两组抑郁评分，分析骨密度值与抑郁评分的相关性，计算血浆IL－6、Cor、ACTH、T、NA、5－HT的水平，探讨抑郁对骨质疏松影响的潜在机制。结果骨质疏松组抑郁评分明显高于对照组（ P＜0．01 ），而年龄和体重指数均无差别。骨密度值与抑郁评分呈负相关（ r＝－0．468， P＝0．02）；骨质疏松组血浆IL－6、Cor、ACTH、NA水平均高于对照组，而血浆睾酮（ P）和5－HT低于对照组。结论老年男性抑郁情绪为原发性骨质疏松的重要危险因素。
목적：연구노년남성억욱정서대원발성골질소송증적영향급기궤제。방법선취우아원노년과주원적노년남성원발성골질소송환자68례（골질소송조）화비골질소송환자66례（대조조），노년억욱량표（ GDS）평고억욱치，쌍능X선측정골밀도，방사면역법측정혈장피질순（Cor）、촉신상선피질격소（ACTH）、고동（T）적수평，매련면역흡부법측정백개소－6（IL－6）、거갑신상선소（NA）、5－간색알（5－HT）수평，비교량조억욱평분，분석골밀도치여억욱평분적상관성，계산혈장IL－6、Cor、ACTH、T、NA、5－HT적수평，탐토억욱대골질소송영향적잠재궤제。결과골질소송조억욱평분명현고우대조조（ P＜0．01 ），이년령화체중지수균무차별。골밀도치여억욱평분정부상관（ r＝－0．468， P＝0．02）；골질소송조혈장IL－6、Cor、ACTH、NA수평균고우대조조，이혈장고동（ P）화5－HT저우대조조。결론노년남성억욱정서위원발성골질소송적중요위험인소。
Objective To investigate the effect and mechanism of depression on primary osteoporosis in elder males.Methods Sixty-eight senile male patients with primary osteoporosis ( osteoporosis group ) and 66 senile male patients without primary osteoporosis ( control group) , who were hospitalized in the Department of Geriatrics in our hospital, were selected.All the patients were assessed using Geriatric Depression Scale ( GDS) .The bone mineral density ( BMD) was detected using dual energy X-ray absorptiometry.The plasma levels of cortisol ( Cor) , adrenocorticotropic hormone ( ACTH) , and testosterone ( T) were determined using radioimmunoassay (RIA) method.The serum levels of interleukin -6 (IL-6), norepinephrine (NA), and 5-serotonin (5-HT) were determined using enzyme linked immunosorbent assay ( ELISA) method.The depression scores between two groups were compared.The correlation between BMD and depression scores was analyzed.The plasma levels of IL-6, Cor, ACTH, T, NA, and 5-HT were calculated and the potential mechanism of depression on primary osteoporosis in senile males was explored.Results The depression scores in osteoporosis group were significantly higher than those in the control group (P<0.01), but no difference in age and body mass index (BMI) was observed.BMD was negatively correlated with depression scores (r=-0.562, P=0.02). The plasma levels of IL-6, Cor, ACTH, and NA in osteoporosis group were higher than those in the control group, but the plasma levels of testosterone ( P) and 5-HT were lower than those in the control group.Conclusion Depression is an important risk factor for primary osteoporosis in the elder males.