CAJ | 학술논문

目的：了解健康年轻（22～37岁）男性和女性人群维生素D状况以及季节对维生素D水平的影响。方法选取在冬春季或夏秋季进行体检的健康年轻男性和女性，共416例，用酶联免疫的方法测定血中25－羟维生素D （25（OH）D）水平。结果所有的受检对象不论季节和性别25（ OH） D水平均明显低于正常值，其中维生素D缺乏和不足（＜75 nmol／L）的比率近90％，其中冬春季节多数为轻中度缺乏（达80％），而夏秋季节以轻度缺乏或不足为主（70％以上）。25（OH）D水平在冬春季节明显低于夏秋季节。此外，不论任何季节，女性组维生素D中重度缺乏的比率明显高于男性组，25（OH）D水平明显低于男性组。结论我国北方地区居住的人群不论季节和性别维生素D缺乏的发病率均很高，特别是年轻女性是维生素D缺乏的高危人群。应采用有效的措施防治维生素D的缺乏，减少维生素D缺乏对健康的影响。
목적：료해건강년경（22～37세）남성화녀성인군유생소D상황이급계절대유생소D수평적영향。방법선취재동춘계혹하추계진행체검적건강년경남성화녀성，공416례，용매련면역적방법측정혈중25－간유생소D （25（OH）D）수평。결과소유적수검대상불론계절화성별25（ OH） D수평균명현저우정상치，기중유생소D결핍화불족（＜75 nmol／L）적비솔근90％，기중동춘계절다수위경중도결핍（체80％），이하추계절이경도결핍혹불족위주（70％이상）。25（OH）D수평재동춘계절명현저우하추계절。차외，불론임하계절，녀성조유생소D중중도결핍적비솔명현고우남성조，25（OH）D수평명현저우남성조。결론아국북방지구거주적인군불론계절화성별유생소D결핍적발병솔균흔고，특별시년경녀성시유생소D결핍적고위인군。응채용유효적조시방치유생소D적결핍，감소유생소D결핍대건강적영향。
Objective To investigate the vitamin D status in young men and women (22-37 years old) and to analyze the effect of season on the level of plasma 25-hydroxyvitamin D [25(OH)D].Methods A total of 416 healthy male and female subjects, who received physical examination during winter to spring or summer to autumn, were selected.The plasma level of 25(OH)D was assessed using enzyme-linked immunosorbent assay.Results The average plasma level of 25 ( OH) D in all subjects was lower than normal range, regardless of season and gender.The overall prevalence of 25(OH)D deficiency and insufficiency (<75 nmol/L) was about 90%.The majority of the subjects ( 80%) had mild or moderate vitamin D deficiency during winter to spring. However, most of the subjects ( over 70%) had mild vitamin D deficiency or insufficiency during summer to autumn.The plasma level of 25(OH)D was lower during winter to spring than that during summer to autumn.Regardless of season, the rate of moderate and severe vitamin D deficiency in females was much higher than that in males, while the plasma 25(OH)D level was lower than that in males.Conclusion Regardless of season and gender, the prevalence of vitamin D deficiency is very high in people living in the northern part of China, especially for young women who are in high risk group of vitamin D deficiency.Effective measures should be taken to prevent vitamin D deficiency and to reduce the effect of vitamin D deficiency on human health.