CAJ | 학술논문

骨粘连蛋白(ON)%Ⅰ型原胶原N-端前肽(PINP)%骨保护素(OPG)%胰岛素样生长因子(IGF-1)%转化生长因子β(TGF-β)%股骨颈骨密度(BMD of the femoral neck) 骨粘連蛋白(ON)%Ⅰ型原膠原N-耑前肽(PINP)%骨保護素(OPG)%胰島素樣生長因子(IGF-1)%轉化生長因子β(TGF-β)%股骨頸骨密度(BMD of the femoral neck)
골점련단백(ON)%Ⅰ형원효원N-단전태(PINP)%골보호소(OPG)%이도소양생장인자(IGF-1)%전화생장인자β(TGF-β)%고골경골밀도(BMD of the femoral neck)
Osteonectin (ON)%I procollagen amino-terminal peptide (PINP)%Ostoeprotegerin (OPG)%Insulin growth factor 1 (IGF-1)%Transforming growth factorβ(TGF-β)%BMD of the femoral neck

目的：研究骨粘连蛋白（ ON）、Ⅰ型原胶原N－端前肽（ PINP）、骨保护素（ OPG）、胰岛素样生长因子1（ IGF－1）、转化生长因子β（ TGF－β）与股骨颈骨密度（ BMD）的相关性。方法采用美国Hologic公司Discovery WA型骨密度仪检测股骨颈BMD，采用美国Thermo公司全自动酶标免疫分析仪检测ON、PINP、OPG、IGF－1、TGF－β。将913例受试者检测结果按10岁为年龄段分组，应用SPSS 13．0分析软件进行统计分析。结果男性与女性正常组血清ON、PINP、IGF－1、TGF－β水平均明显高于骨质疏松组，而正常组血清OPG水平均明显低于骨质疏松组（P＜0．05）。女性血清ON、PINP、IGF－1、TGF－β水平与股骨颈BMD呈正相关（P＜0．05），OPG水平与股骨颈BMD呈负相关（P＜0．05）。男性血清ON、IGF－1、TGF－β水平与股骨颈BMD呈正相关（P＜0．05），OPG水平与股骨颈BMD呈负相关（P＜0．05）。结论血清ON、PINP、IGF－1、TGF－β水平与股骨颈BMD正相关，血清OPG水平与股骨颈BMD负相关。 ON、PINP、OPG、IGF－1、TGF－β在骨代谢过程中相互作用影响骨质量，与股骨颈BMD存在重要关联。
목적：연구골점련단백（ ON）、Ⅰ형원효원N－단전태（ PINP）、골보호소（ OPG）、이도소양생장인자1（ IGF－1）、전화생장인자β（ TGF－β）여고골경골밀도（ BMD）적상관성。방법채용미국Hologic공사Discovery WA형골밀도의검측고골경BMD，채용미국Thermo공사전자동매표면역분석의검측ON、PINP、OPG、IGF－1、TGF－β。장913례수시자검측결과안10세위년령단분조，응용SPSS 13．0분석연건진행통계분석。결과남성여녀성정상조혈청ON、PINP、IGF－1、TGF－β수평균명현고우골질소송조，이정상조혈청OPG수평균명현저우골질소송조（P＜0．05）。녀성혈청ON、PINP、IGF－1、TGF－β수평여고골경BMD정정상관（P＜0．05），OPG수평여고골경BMD정부상관（P＜0．05）。남성혈청ON、IGF－1、TGF－β수평여고골경BMD정정상관（P＜0．05），OPG수평여고골경BMD정부상관（P＜0．05）。결론혈청ON、PINP、IGF－1、TGF－β수평여고골경BMD정상관，혈청OPG수평여고골경BMD부상관。 ON、PINP、OPG、IGF－1、TGF－β재골대사과정중상호작용영향골질량，여고골경BMD존재중요관련。
Objective To investigate the correlation between osteonectin ( ON ) , type I procollagen amino-terminal peptide ( PINP) , osteoprotegerin ( OPG) , insulin growth factor 1 ( IGF-1) , transforming growth factorβ( TGF-β) , and the bone mineral density ( BMD) of the femoral neck.Methods BMD of the femoral neck was detected using the bone mineral density detector (Hologic Discovery-WA, USA).The serum levels of ON, PINP, OPG, IGF-1, and TGF-βwere detected using automatic enzyme immunoassay analyzer ( Thermo, USA) .All the 913 subjects were divided into different groups according to a 10-year range.All the data were analyzed using a SPSS 13.0 software.Results The serum levels of ON, PINP, IGF-1, and TGF-βin male and female subjects in normal group were significantly higher than those in osteoporosis group, while the serum level of OPG in normal group was significantly lower than that in osteoporosis group (P<0.05).The serum levels of ON, PINP, IGF-1, and TGF-βin females were positively correlated with BMD of the femoral neck (P<0.05), while the OPG level was negatively correlated with BMD of the femoral neck (P<0.05).The serum levels of ON, IGF-1, and TGF-βin males were positively correlated with BMD of the femoral neck ( P <0.05 ) , while the OPG level was negatively correlated with BMD of the femoral neck ( P <0.05 ) . Conclusion The serum levels of ON, PINP, IGF-1, and TGF-βare positively correlated with BMD of the femoral neck, but the OPG level was negatively correlated with BMD of the femoral neck.In the process of bone metabolism, ON, PINP, OPG, IGF-1, and TGF-βcan affect bone mass through their interaction.They have a significant association with BMD of the femoral neck.