国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2009年
10期
739-741
,共3页
端粒%端粒结合蛋白质类%细胞周期%染色体不稳定性
耑粒%耑粒結閤蛋白質類%細胞週期%染色體不穩定性
단립%단립결합단백질류%세포주기%염색체불은정성
Telomere%Telomere-hinding proteins%Cell cycle%Chromosomal instability
肿瘤发生与端粒维持密切相关,大部分肿瘤细胞的端粒维持是通过端粒酶途径,而少部分肿瘤细胞是通过非端粒酶依赖途径,即所谓的端粒替代延长机制实现端粒维持.端粒延长途径的选择在不同水平如细胞、蛋白、基因水平会受多因素的影响即端粒本身结构的完整性、染色体的稳定性、细胞周期、组蛋白等因素影响.了解这些影响因素,有利于进一步研究阻断端粒延长途径的药物,从而控制肿瘤的无限增长,有效治疗肿瘤.
腫瘤髮生與耑粒維持密切相關,大部分腫瘤細胞的耑粒維持是通過耑粒酶途徑,而少部分腫瘤細胞是通過非耑粒酶依賴途徑,即所謂的耑粒替代延長機製實現耑粒維持.耑粒延長途徑的選擇在不同水平如細胞、蛋白、基因水平會受多因素的影響即耑粒本身結構的完整性、染色體的穩定性、細胞週期、組蛋白等因素影響.瞭解這些影響因素,有利于進一步研究阻斷耑粒延長途徑的藥物,從而控製腫瘤的無限增長,有效治療腫瘤.
종류발생여단립유지밀절상관,대부분종류세포적단립유지시통과단립매도경,이소부분종류세포시통과비단립매의뢰도경,즉소위적단립체대연장궤제실현단립유지.단립연장도경적선택재불동수평여세포、단백、기인수평회수다인소적영향즉단립본신결구적완정성、염색체적은정성、세포주기、조단백등인소영향.료해저사영향인소,유리우진일보연구조단단립연장도경적약물,종이공제종류적무한증장,유효치료종류.
Telomere maintenance is correlated with the genesis of tumor,majority of tumors depend on the telomerase to maintain its function,but minority of tumors use pathway independent of the telomernse,that is the alternative way of lengthening(ALT).This choice of pathway is determined by several factors in different aspects,such as cells level,proteins level and genes level,the factors include the integrity of the telomere,the chromosome stability,the cell cycle and histone.Complete understandings of these factors help us to find some drugs to inhibit this alternative pathway and control the progression of the tumor,and then we can treat tumors more efficiently.