中国疗养医学
中國療養醫學
중국요양의학
CHINESE JOURNAL OF CONVALESCENT MEDICINE
2014年
12期
1069-1071
,共3页
甘景梨%段惠峰%程正祥%杨家明%田秀丽%赵兰民%高存友%祝希泉%梁学军
甘景梨%段惠峰%程正祥%楊傢明%田秀麗%趙蘭民%高存友%祝希泉%樑學軍
감경리%단혜봉%정정상%양가명%전수려%조란민%고존우%축희천%량학군
抑郁症%认知功能%磁共振波谱
抑鬱癥%認知功能%磁共振波譜
억욱증%인지공능%자공진파보
D epression%C ognitive function%M agnetic resonace spectroscopy
目的:探讨抑郁症患者认知功能与前额叶、海马氢质子磁共振波谱(1H-MRS)特点及其之间的相关性。方法研究对象为2010-12—2012-11在我院住院的51例抑郁症患者(研究组)及附近社区的46例正常对照(对照组)。入组24 h内应用事件相关电位P30( P30)和威斯康星卡片分类测验( WCST )评估认知功能,采用多体素1H-MRS检测前额叶和海马N-乙酰基天门冬氨酸( NAA )、胆碱复合物( Cho )与肌酸复合物( Cr )。结果与对照组比较,研究组N2、P3潜伏期均延长,N2、P3波幅均降低,差异有高度统计学意义(t值分别为3.258、5.834、4.707和-4.968,P<0.01);Re、Rpe、Rf均高,Cc和Rf%均低,差异有高度统计学意义(t值分别为4.969、5.682、3.001、-3.649和-4.269,P<0.01)。研究组NAA/Cr值左侧和右侧前额叶、左侧海马均低于对照组,差异有统计学意义[(1.74±0.28)vs(1.87±0.16),t=2.767,P=0.007;(1.73±0.32)vs(1.89±0.15),t=2.315,P=0.023;(1.75±0.33)vs(1.87±0.27), t=2.641,P=0.001]。研究组左侧前额叶、左侧海马的NAA/Cr值与P3波幅、Cc、Rf%等均呈正相关(r=0.352,0.324,0.337;0.344,0.312,0.334,P<0.05),与P3潜伏期、Re、Rpe、Rf等均呈负相关(r=-0.354,-0.353,-0.370,-0.296;-0.352,-0.356,-0.364,-0.302,P<0.05)。结论抑郁症患者存在认知功能损害,可能与前额叶、海马的神经元低水平表达有关。
目的:探討抑鬱癥患者認知功能與前額葉、海馬氫質子磁共振波譜(1H-MRS)特點及其之間的相關性。方法研究對象為2010-12—2012-11在我院住院的51例抑鬱癥患者(研究組)及附近社區的46例正常對照(對照組)。入組24 h內應用事件相關電位P30( P30)和威斯康星卡片分類測驗( WCST )評估認知功能,採用多體素1H-MRS檢測前額葉和海馬N-乙酰基天門鼕氨痠( NAA )、膽堿複閤物( Cho )與肌痠複閤物( Cr )。結果與對照組比較,研究組N2、P3潛伏期均延長,N2、P3波幅均降低,差異有高度統計學意義(t值分彆為3.258、5.834、4.707和-4.968,P<0.01);Re、Rpe、Rf均高,Cc和Rf%均低,差異有高度統計學意義(t值分彆為4.969、5.682、3.001、-3.649和-4.269,P<0.01)。研究組NAA/Cr值左側和右側前額葉、左側海馬均低于對照組,差異有統計學意義[(1.74±0.28)vs(1.87±0.16),t=2.767,P=0.007;(1.73±0.32)vs(1.89±0.15),t=2.315,P=0.023;(1.75±0.33)vs(1.87±0.27), t=2.641,P=0.001]。研究組左側前額葉、左側海馬的NAA/Cr值與P3波幅、Cc、Rf%等均呈正相關(r=0.352,0.324,0.337;0.344,0.312,0.334,P<0.05),與P3潛伏期、Re、Rpe、Rf等均呈負相關(r=-0.354,-0.353,-0.370,-0.296;-0.352,-0.356,-0.364,-0.302,P<0.05)。結論抑鬱癥患者存在認知功能損害,可能與前額葉、海馬的神經元低水平錶達有關。
목적:탐토억욱증환자인지공능여전액협、해마경질자자공진파보(1H-MRS)특점급기지간적상관성。방법연구대상위2010-12—2012-11재아원주원적51례억욱증환자(연구조)급부근사구적46례정상대조(대조조)。입조24 h내응용사건상관전위P30( P30)화위사강성잡편분류측험( WCST )평고인지공능,채용다체소1H-MRS검측전액협화해마N-을선기천문동안산( NAA )、담감복합물( Cho )여기산복합물( Cr )。결과여대조조비교,연구조N2、P3잠복기균연장,N2、P3파폭균강저,차이유고도통계학의의(t치분별위3.258、5.834、4.707화-4.968,P<0.01);Re、Rpe、Rf균고,Cc화Rf%균저,차이유고도통계학의의(t치분별위4.969、5.682、3.001、-3.649화-4.269,P<0.01)。연구조NAA/Cr치좌측화우측전액협、좌측해마균저우대조조,차이유통계학의의[(1.74±0.28)vs(1.87±0.16),t=2.767,P=0.007;(1.73±0.32)vs(1.89±0.15),t=2.315,P=0.023;(1.75±0.33)vs(1.87±0.27), t=2.641,P=0.001]。연구조좌측전액협、좌측해마적NAA/Cr치여P3파폭、Cc、Rf%등균정정상관(r=0.352,0.324,0.337;0.344,0.312,0.334,P<0.05),여P3잠복기、Re、Rpe、Rf등균정부상관(r=-0.354,-0.353,-0.370,-0.296;-0.352,-0.356,-0.364,-0.302,P<0.05)。결론억욱증환자존재인지공능손해,가능여전액협、해마적신경원저수평표체유관。
Objective To explore the relationship betw een cognitive function,prefrontal lobe,and hippocam pus 1H-m agnetic resonance spectroscopy (1H-M R S )am ong depression sufferers.Methods 51 depression sufferers adm itted to our hospital from D ecem ber 2010 to N ovem ber 2012 w ere chosen to be the research group ,w hile 46 norm al cases w ere chosen to be the control group .E vent-related potential (ERP)P30 andWisconsinCardSortingTest(WCST)wereadoptedtoassesscognitivefunctionwithin24hoursofadmission,andmulti-vox-el 1H-M R S w as adopted to detect prefrontal lobe,hippocam pus N-acetyl-aspartate (N A A ),C ho and C r.Results C om pared w ith the control group,the research group show ed prolonged latency of N 2 and P3,shortened am plitude of N 2 and P3,w ith differences of high statistical significance(t=3.258,5.834,4.707,-4.968,P<0.01).And they also dem onstrated high Re,Rpe,and Rf,and low Cc and Rf% ,with differences of high statistical significance (t=4 .969 ,5 .682 ,3 .001 ,-3 .649 ,-4 .269 ,P<0 .01 ).T he N A A/C r ratios in left and right pre-frontal lobes[(1.74±0.28)vs(1.87±0.16),t=2.767,P=0.007;(1.73±0.32)vs(1.89±0.15),t=2.315,P=0.023]and left hip-pocam pus[(1 .75 ± 0 .33 )vs(1 .87 ± 0 .27 ),t=2 .641 ,P=0 .001 )]in the research group w ere low er than the control group w ith differences of high statistical significance.T he N A A/C r ratios in both left prefrontal lobe and left hippocam pus in the research group w ere positively related to the am plitude of P3,C c,and R f% (r=0.352,0.324,0.337;0.344,0.312,0.334,P<0.05),and negatively related to the latency of P3, R e,R pe,and R f (r=-0.354,-0.353,-0.370,-0.296;-0.352,-0.356,-0.364,-0.302,P<0.05).Conclusions C ognition dys-function in depression sufferers is perhaps related to the low level expression of nerve cells in prefrontal lobe and hippocam pus.