CAJ | 학술논문

目的：优选舒胸舌下片辅料配方和舌下黏膜促透剂配方。方法按正交实验设计，优选乳糖、甘露醇、微晶纤维素最佳比例；采用Frank扩散池进行体外扩散实验，HPLC 测定人参皂苷 Rg1的累积透膜量，按星点设计－效应面法设计实验，优选氮酮、油酸和薄荷醇的最佳比例。结果舌下片最佳制备工艺为药材提取物－〔乳糖－甘露醇（1∶9）〕－微晶纤维素为6∶8∶0．5加2％的氮酮、2％的油酸、5％薄荷醇复合促透剂制片。结论舒胸舌下片辅料配方能保证片剂的性状参数，复合黏膜促透作用稳定。
목적：우선서흉설하편보료배방화설하점막촉투제배방。방법안정교실험설계，우선유당、감로순、미정섬유소최가비례；채용Frank확산지진행체외확산실험，HPLC 측정인삼조감 Rg1적루적투막량，안성점설계－효응면법설계실험，우선담동、유산화박하순적최가비례。결과설하편최가제비공예위약재제취물－〔유당－감로순（1∶9）〕－미정섬유소위6∶8∶0．5가2％적담동、2％적유산、5％박하순복합촉투제제편。결론서흉설하편보료배방능보증편제적성상삼수，복합점막촉투작용은정。
Objective prepare shuxiong sublingual tablet and study the sublingual mucosa permeation enhancer .Methods The sublingual tablets was made by lactose ,mannitol and MCC orthogonal test .According to central composite design-response surface methodolo-gy, drug vitro permeation tests were performed in Frank diffusion cell .The accumulation transmittance of Ginsenoside Rg 1 concentration in samples was determined by HPLC.Results The sublingual tablet was made by dry extract powders:lactose and mannitol(1:9):MCC=6:8:0.5.The best complex accelerators were composed of 2 percent Azone, 2 percent Oleic acid and 5 percent menthol.Conclusions Shux-iong sublingual tablet preparation process is reasonable and composite membrane agent penetration effect is stable .