CAJ | 학술논문

核不均一性核糖核蛋白（heterogeneous nuclear ribonucleoprotein，hnRNP）家族是一组调节前体mRNA（pre-mRNA）分子的选择性剪接以及mRNA转运、翻译和稳定性等的多功能RNA结合蛋白。hnRNP A1和hnRNP A2是该家族中表达水平最高、研究最为广泛的成员，两者具有高度的序列同源型和功能相似性，在多种肿瘤组织中高表达，通过调节多种肿瘤相关基因pre-mRNA选择性剪接和mRNA稳定性，参与调控了肿瘤细胞的增殖、凋亡、肿瘤相关的炎症与免疫反应、上皮-间质转换等多种细胞生物学过程，从而成为肿瘤发病分子机制以及肿瘤诊断和治疗领域研究的热点。
핵불균일성핵당핵단백（heterogeneous nuclear ribonucleoprotein，hnRNP）가족시일조조절전체mRNA（pre-mRNA）분자적선택성전접이급mRNA전운、번역화은정성등적다공능RNA결합단백。hnRNP A1화hnRNP A2시해가족중표체수평최고、연구최위엄범적성원，량자구유고도적서렬동원형화공능상사성，재다충종류조직중고표체，통과조절다충종류상관기인pre-mRNA선택성전접화mRNA은정성，삼여조공료종류세포적증식、조망、종류상관적염증여면역반응、상피-간질전환등다충세포생물학과정，종이성위종류발병분자궤제이급종류진단화치료영역연구적열점。
Heterogeneous nuclear ribonucleoprotein (hnRNP) is a family of multifunctional nuclear RNA-binding proteins that regulate the alternative splicing of pre-mRNA and the transport, translation, and stability of mRNA. The most abundant and best charac-terized proteins of this group are hnRNP A1 and hnRNP A2, which share a high degree of sequence homology and functional similarity. HnRNP A1 and hnRNP A2 are upregulated in multiple human tumors and modulate the alternative splicing and mRNA stability of vari-ous tumor-related genes critical to tumor cell growth, apoptosis, inflammatory and immune reactions, and epithelial-to-mesenchymal transition. Therefore, hnRNP A1 and hnRNP A2 have potential diagnostic, prognostic, and therapeutic values.