CAJ | 학술논문

目的：探讨急性脑梗死患者血浆非对称性二甲基精氨酸（ADMA）水平与血清同型半胱氨酸（Hcy）水平的相关性。方法将126例急性脑梗死患者（脑梗死组）依据美国国立卫生研究所卒中量表评分（ NIHSS）得分，分为轻、中及重型三个亚组；同期健康体检者60例作为对照组。采用酶联免疫吸附法检测血浆ADMA浓度；化学发光法检测血清Hcy浓度。比较组间血浆 ADMA及血清Hcy水平；分析血浆 ADMA与血清Hcy水平的相关性。结果急性脑梗死各亚组及对照组血浆 ADMA浓度分别为[（48．69±33．27）；（62．69±28．80）；（83．58±21．27）；（21．93±7．03）μmol／L]，组间多重比较差异均有统计学意义（P＜0．05）。血清Hcy浓度分别为[（12．99±8．78）；（15．99±7．74）；（22．16±7．35）；（11．97±4．87）μmol／L]，轻型梗死组与对照组比较差异无统计学意义（P＞0．05）。中型、重型梗死组与对照组比较差异均有统计学意义（P＜0．05）。相关分析发现，血浆 AD－MA与血清Hcy水平存在正相关（r＝0．885，P＝0．000）多因素线性逐步回归分析发现，血浆ADMA与血清Hcy水平呈线性趋势（B＝2．404，P＜0．01）。结论急性脑梗死患者血浆ADMA、血清Hcy水平均升高，且血浆ADMA与血清Hcy水平呈正相关。
목적：탐토급성뇌경사환자혈장비대칭성이갑기정안산（ADMA）수평여혈청동형반광안산（Hcy）수평적상관성。방법장126례급성뇌경사환자（뇌경사조）의거미국국립위생연구소졸중량표평분（ NIHSS）득분，분위경、중급중형삼개아조；동기건강체검자60례작위대조조。채용매련면역흡부법검측혈장ADMA농도；화학발광법검측혈청Hcy농도。비교조간혈장 ADMA급혈청Hcy수평；분석혈장 ADMA여혈청Hcy수평적상관성。결과급성뇌경사각아조급대조조혈장 ADMA농도분별위[（48．69±33．27）；（62．69±28．80）；（83．58±21．27）；（21．93±7．03）μmol／L]，조간다중비교차이균유통계학의의（P＜0．05）。혈청Hcy농도분별위[（12．99±8．78）；（15．99±7．74）；（22．16±7．35）；（11．97±4．87）μmol／L]，경형경사조여대조조비교차이무통계학의의（P＞0．05）。중형、중형경사조여대조조비교차이균유통계학의의（P＜0．05）。상관분석발현，혈장 AD－MA여혈청Hcy수평존재정상관（r＝0．885，P＝0．000）다인소선성축보회귀분석발현，혈장ADMA여혈청Hcy수평정선성추세（B＝2．404，P＜0．01）。결론급성뇌경사환자혈장ADMA、혈청Hcy수평균승고，차혈장ADMA여혈청Hcy수평정정상관。
Objective To explore the correlation between plasma asymmetric dimethylarginine ( ADMA) and serum homocysteine-mia(Hcy)of patients with acute cerebral infarction (ACI) .Methods 126 ACI patients were divided into three groups based on different scores of U.S.national institutes of health stroke scale(NIHSS scores):light,midsize,severe cerebral infarction.At the corresponding period, there were 60 healthy subjects in control group.Level of plasma ADMA was detected by enzyme linked immunosorbent assay (ELISA),and serum Hcy level was detected by Chemiluminescence ,and the correlation between ADMA and Hcy was analyzed .Results Levels of plasma ADMA were 〔(48.69±33.27),(62.69±28.80),(83.58±21.27),(21.93±7.03)μmol/L,respectively〕and serum Hcy were〔(12.99± 8.78);(15.99±7.74);(22.16±7.35);(11.97±4.87) μmol/L,respectively〕in three ACI groups and control group (P<0.05).The linear stepwise regression analysis showed that there was linear tendency between the levels of ADMA and Hcy (B=2.404,P<0.01).Conclusions Levels of plasma ADMA and serum Hcy are significantly increased in ACI patients .There is a correlation between levels of plasma ADMA and serum Hcy.