中国卫生产业
中國衛生產業
중국위생산업
CHINA HEALTH INDUSTRY
2014年
32期
24-25
,共2页
多发性骨髓瘤%肾损害%临床分析
多髮性骨髓瘤%腎損害%臨床分析
다발성골수류%신손해%림상분석
Multiple myeloma%Renal impairment%Clinical analysis
目的：观察多发性骨髓瘤(MM)肾损害的临床表现及相关因素。方法回顾性分析我院65例MM患者临床资料，应用Cockcroft-Gault方程评估肾功能，按Ccr小于60mL/min/1.73 m2与大等于60mL/min/1.73m2将患者分为A、B两组，进行两组间临床资料的比较。结果 A组β2微球蛋白、尿酸、血钙、尿轻链蛋白、贫血发生率均高于B组，(P<0.05)。β2微球蛋白、尿酸、血钙、尿轻链蛋白、血红蛋白水平对肾功能均有明显影响。结论 MM肾损害有一定的临床特点，肾损害与β2微球蛋白、尿酸、血钙、尿轻链蛋白、贫血关系密切。
目的：觀察多髮性骨髓瘤(MM)腎損害的臨床錶現及相關因素。方法迴顧性分析我院65例MM患者臨床資料，應用Cockcroft-Gault方程評估腎功能，按Ccr小于60mL/min/1.73 m2與大等于60mL/min/1.73m2將患者分為A、B兩組，進行兩組間臨床資料的比較。結果 A組β2微毬蛋白、尿痠、血鈣、尿輕鏈蛋白、貧血髮生率均高于B組，(P<0.05)。β2微毬蛋白、尿痠、血鈣、尿輕鏈蛋白、血紅蛋白水平對腎功能均有明顯影響。結論 MM腎損害有一定的臨床特點，腎損害與β2微毬蛋白、尿痠、血鈣、尿輕鏈蛋白、貧血關繫密切。
목적：관찰다발성골수류(MM)신손해적림상표현급상관인소。방법회고성분석아원65례MM환자림상자료，응용Cockcroft-Gault방정평고신공능，안Ccr소우60mL/min/1.73 m2여대등우60mL/min/1.73m2장환자분위A、B량조，진행량조간림상자료적비교。결과 A조β2미구단백、뇨산、혈개、뇨경련단백、빈혈발생솔균고우B조，(P<0.05)。β2미구단백、뇨산、혈개、뇨경련단백、혈홍단백수평대신공능균유명현영향。결론 MM신손해유일정적림상특점，신손해여β2미구단백、뇨산、혈개、뇨경련단백、빈혈관계밀절。
Objective To investigate the clinical features of renal impairment in patients with multiple myeloma(MM) and analyze the relevant factors. Methods Retrospective analysis of clinical data of 65 patients with MM . Renal function was evaluated by Cockcroft-Gault equations. According to the Ccr,Patients were divided into two groups:group A: Ccr<60mL/ min/( 1.73m2); group B:Ccr≥60mL/ min/(1.73m2). Then comparison of the clinical data between them.Results Compared with group B, group A beta-2 microglobulin, uric acid, blood calcium, urinary protein light chain, the incidence of anemia all higher (P<0.05). beta-2 microglob-ulin, uric acid, blood calcium, urinary protein light chain, hemoglobin levels all adverse renalfunction obviously. Conclusion Renal damage in MM has certain clinical features. IT have close relationship to beta 2 microglobulin, uric acid, blood calcium, urinary protein light chain, anemia.
