CAJ | 학술논문

目的：探讨替罗非班联合阿托伐他汀在急性ST段抬高型心肌梗死急诊冠脉介入中的治疗效果。方法180例急性ST段抬高型心肌梗死患者，随机分为观察组和对照组，每组90例。两组均实施经皮冠状动脉介入治疗，均同时给予阿托伐他汀，观察组同时给予替罗非班。观察两组患者冠脉血流改善情况以及主要不良心脏事件和出血并发症发生情况。结果观察组术后梗死相关血管血流TIMI 3级所占比例高于对照组，差异有统计学意义(P<0.05)；观察组主要不良心脏事件发生率低于对照组，差异有统计学意义(P<0.05)；观察组出血并发症发生率和对照组比较，差异无统计学意义(P>0.05)。结论替罗非班联合阿托伐他汀在急性ST段抬高型心肌梗死急诊冠脉介入治疗中的临床效果显著，值得借鉴。
목적：탐토체라비반연합아탁벌타정재급성ST단태고형심기경사급진관맥개입중적치료효과。방법180례급성ST단태고형심기경사환자，수궤분위관찰조화대조조，매조90례。량조균실시경피관상동맥개입치료，균동시급여아탁벌타정，관찰조동시급여체라비반。관찰량조환자관맥혈류개선정황이급주요불양심장사건화출혈병발증발생정황。결과관찰조술후경사상관혈관혈류TIMI 3급소점비례고우대조조，차이유통계학의의(P<0.05)；관찰조주요불양심장사건발생솔저우대조조，차이유통계학의의(P<0.05)；관찰조출혈병발증발생솔화대조조비교，차이무통계학의의(P>0.05)。결론체라비반연합아탁벌타정재급성ST단태고형심기경사급진관맥개입치료중적림상효과현저，치득차감。
Objective To explore the effect of tirofiban combined with atorvastatin in emergency coronary intervention of acute ST segment elevation myocardial infarction. Methods A total of 180 patients with acute ST segment elevation myocardial infarction were randomly divided into observation group and control group, with 90 cases in each group. Both groups underwent percutaneous coronary intervention and received atorvastatin, while the observation group received additional tirofiban for treatment. The change of coronary blood flow, major adverse cardiac events and bleeding complications in the two groups were observed. Results The proportion of postoperative infarct-related artery blood flow TIMI 3 grade in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The incidence of major adverse cardiac events in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). The incidence of bleeding complications in the observation group had no significant difference, compared with that in the control group (P>0.05). Conclusion The effect of tirofiban combined with atorvastatin in emergency coronary intervention of acute ST segment elevation myocardial infarction is significant, and the method is worth referring.