中国临床医学
中國臨床醫學
중국림상의학
CLINICAL MEDICAL JOURNAL OF CHINA
2014年
5期
586-588
,共3页
寻常型银屑病%钙泊三醇倍他米松%卡泊三醇%糠酸莫米松%窄谱中波紫外线
尋常型銀屑病%鈣泊三醇倍他米鬆%卡泊三醇%糠痠莫米鬆%窄譜中波紫外線
심상형은설병%개박삼순배타미송%잡박삼순%강산막미송%착보중파자외선
Psoriasis vulgaris%Calcipotriol betamethasone%Calcipotriol%Mometasone furoate%Narrow-band ultravi-olet B
目的：观察钙泊三醇倍他米松软膏、卡泊三醇软膏和糠酸莫米松乳膏分别与窄谱中波紫外线（NB-UVB）照射联合治疗寻常型银屑病的效果与不良反应。方法：将90例稳定期寻常型银屑病患者随机分为3组，每组30例。治疗组予钙泊三醇倍他米松软膏，对照组 A 予卡泊三醇软膏，对照组 B 予糠酸莫米松乳膏。3组均将药物涂擦于皮肤损伤部位，每日1次；均在治疗过程中接受 NB-UVB 照射，3次／周；3组患者的疗程均为4周。治疗过程中每周观察1次疗效。结果：治疗2周时，治疗组的有效率（36．67％）高于对照组 A（13．33％）和对照组 B（13．33％），差异有统计学意义（P ＜0．05）；治疗4周时，治疗组有效率（93．33％）高于对照组 A（73．33％）与对照组 B（66．67％），差异有统计学意义（P ＜0．05）。钙泊三醇倍他米松的主要不良反应为灼热和红斑，但患者可耐受。结论：钙泊三醇倍他米松软膏、卡泊三醇软膏和糠酸莫米松乳膏与 NB-UVB 联合应用治疗寻常型银屑病均安全有效，其中以钙泊三醇倍他米松软膏的起效最快、疗效最好、不良反应最少。
目的：觀察鈣泊三醇倍他米鬆軟膏、卡泊三醇軟膏和糠痠莫米鬆乳膏分彆與窄譜中波紫外線（NB-UVB）照射聯閤治療尋常型銀屑病的效果與不良反應。方法：將90例穩定期尋常型銀屑病患者隨機分為3組，每組30例。治療組予鈣泊三醇倍他米鬆軟膏，對照組 A 予卡泊三醇軟膏，對照組 B 予糠痠莫米鬆乳膏。3組均將藥物塗抆于皮膚損傷部位，每日1次；均在治療過程中接受 NB-UVB 照射，3次／週；3組患者的療程均為4週。治療過程中每週觀察1次療效。結果：治療2週時，治療組的有效率（36．67％）高于對照組 A（13．33％）和對照組 B（13．33％），差異有統計學意義（P ＜0．05）；治療4週時，治療組有效率（93．33％）高于對照組 A（73．33％）與對照組 B（66．67％），差異有統計學意義（P ＜0．05）。鈣泊三醇倍他米鬆的主要不良反應為灼熱和紅斑，但患者可耐受。結論：鈣泊三醇倍他米鬆軟膏、卡泊三醇軟膏和糠痠莫米鬆乳膏與 NB-UVB 聯閤應用治療尋常型銀屑病均安全有效，其中以鈣泊三醇倍他米鬆軟膏的起效最快、療效最好、不良反應最少。
목적：관찰개박삼순배타미송연고、잡박삼순연고화강산막미송유고분별여착보중파자외선（NB-UVB）조사연합치료심상형은설병적효과여불량반응。방법：장90례은정기심상형은설병환자수궤분위3조，매조30례。치료조여개박삼순배타미송연고，대조조 A 여잡박삼순연고，대조조 B 여강산막미송유고。3조균장약물도찰우피부손상부위，매일1차；균재치료과정중접수 NB-UVB 조사，3차／주；3조환자적료정균위4주。치료과정중매주관찰1차료효。결과：치료2주시，치료조적유효솔（36．67％）고우대조조 A（13．33％）화대조조 B（13．33％），차이유통계학의의（P ＜0．05）；치료4주시，치료조유효솔（93．33％）고우대조조 A（73．33％）여대조조 B（66．67％），차이유통계학의의（P ＜0．05）。개박삼순배타미송적주요불량반응위작열화홍반，단환자가내수。결론：개박삼순배타미송연고、잡박삼순연고화강산막미송유고여 NB-UVB 연합응용치료심상형은설병균안전유효，기중이개박삼순배타미송연고적기효최쾌、료효최호、불량반응최소。
Objective:To observe the efficacy and safety of calcipotriol betamethasone ointment,calcipotriol ointment and mo-metasone furoate cream respectively combined with narrow-band ultraviolet B(NB-UVB)in the treatment of psoriasis vulgaris. Methods:Ninety patients of psoriasis vulgaris were randomly divided into three groups,with 30 cases in each group.Thirty pa-tients in the treatment group were treated with calcipotriol betamethasone ointment;thirty patients in the control group A were treated with calcipotriol ointment,and thirty patients in the control group B were treated with mometasone furoate cream.All the three groups were given specific medications once daily by applying to the skin lesions.NB-UVB treatment was applied three times a week during the period of medication treatment.The duration of treatment was four weeks.Efficacy was observed once a week during the treatment.Results:At week 2 of the treatment,the effective rate in the treatment group was 36.67%, which was higher than that in the control group A(13.33%)and control group B (13.33%).The difference was significant (P <0.05)Observation at week 4 showed that the efficacy of the treatment group was better than that of the two control groups.The difference was statistically significant (P < 0.05).Adverse events of the treatment group mainly included skin burning sensation and erythema which could be tolerated.Conclusions:Calcipotriol betamethasone ointment,calcipotriol oint-ment and mometasone furoate cream respectively combined with NB-UVB were efficacious and safe in the treatment of psoriasis vulgaris.However,calcipotriol betamethasone ointment takes faster and better effect,and less adverse reaticons.
