CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease，AECOPD）患者血清和痰液中表面活性蛋白 D （surfactant protein D，SP-D）的水平和临床意义。方法：选取急性加重期 COPD（acute exacerbation of COPD，AECOPD）患者34例（A 组）、稳定期 COPD 患者37例（B 组）、有嗜烟史的健康人30例（C 组）、无嗜烟史的健康人30例（D 组）。分别检测4组血清和痰液中的 SP-D 水平，并分析 AECOPD 患者血清和痰液 SP-D 水平的相关性。结果：A、B、C、D 组的血清 SP-D 水平依次为（165．09±16．72）、（126．48±15．64）、（72．85±8．62）、（54．70±7．29）ng／mL，痰液 SP-D 水平依次为（109．03±18．95）、（133．28±16．36）、（260．04±47．91）、（665．89±117．49）ng／mL；血清和痰液 SP-D 水平在4组间的差异均有统计学意义（P ＜0．05）。AECOPD 患者的血清 SP-D 水平和痰液 SP-D 水平呈负相关（r＝－0．698，P ＜0．05）。结论：AECOPD 患者的血清、痰液 SP-D 水平呈负相关。血清、痰液 SP-D 水平的监测有助于临床 AECOPD 病情的评估。
목적：탐토만성조새성폐질병（chronic obstructive pulmonary disease，AECOPD）환자혈청화담액중표면활성단백 D （surfactant protein D，SP-D）적수평화림상의의。방법：선취급성가중기 COPD（acute exacerbation of COPD，AECOPD）환자34례（A 조）、은정기 COPD 환자37례（B 조）、유기연사적건강인30례（C 조）、무기연사적건강인30례（D 조）。분별검측4조혈청화담액중적 SP-D 수평，병분석 AECOPD 환자혈청화담액 SP-D 수평적상관성。결과：A、B、C、D 조적혈청 SP-D 수평의차위（165．09±16．72）、（126．48±15．64）、（72．85±8．62）、（54．70±7．29）ng／mL，담액 SP-D 수평의차위（109．03±18．95）、（133．28±16．36）、（260．04±47．91）、（665．89±117．49）ng／mL；혈청화담액 SP-D 수평재4조간적차이균유통계학의의（P ＜0．05）。AECOPD 환자적혈청 SP-D 수평화담액 SP-D 수평정부상관（r＝－0．698，P ＜0．05）。결론：AECOPD 환자적혈청、담액 SP-D 수평정부상관。혈청、담액 SP-D 수평적감측유조우림상 AECOPD 병정적평고。
Objective:To explore the levels and clinical significance of serum and sputum surfactant protein D (SP-D)in pa-tients with chronic obstructive pulmonary disease (AECOPD).Methods:Thirty-four patients with AECOPD (Group A),37 patients with stable COPD (Group B),30 healthy people with smoking history (Group C),and 30 helthy people without smok-ing history (Group D)were enrolled.SP-D levels in the serum and sputum of the four groups were detected and compared. Moreover,the correlation between serum SP-D level and sputum SP-D level in patients with AECOPD was analyzed.Results:The serum SP-D levels in Group A,Group B,Group C and Group D were (165.09±16.72)ng/mL,(126.48± 15.64)ng/mL, (72.85±8.62)ng/mL and(54.70±7.29)ng/mL,respectively.The sputum SP-D levels in Group A,Group B,Group C and Group D were (109.03 ± 18.95)ng/mL,(133.28± 16.36)ng/mL,(260.04±47.91)ng/mL and(665.89± 117.49)ng/mL. There were significant differences in the levels of serum and sputum SP-D among the four groups(P <0.05).Serum SP-D level and sputum SP-D level in patients with AECOPD were negatively correlated (r=-0.698,P <0.05).Conclusions:The detec-tion of SP-D levels in serum and sputum contributes to the clinical assessment of AECOPD.There is a negative correlation be-tween serum SP-D level and sputum SP-D level in AECOPD patients.